(2R)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-(aminomethyl)-2-benzyl-3-methylbutanoate

Base Information

Chemical Name:(2R)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-(aminomethyl)-2-benzyl-3-methylbutanoate
CAS No.:154520-28-2
Molecular Formula:C₃₅H₅₆N₂O₄S
Molecular Weight:600.907
Hs Code.:

Synonyms:(2R)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-(aminomethyl)-2-benzyl-3-methylbutanoate

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Chemical Property of (2R)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-(aminomethyl)-2-benzyl-3-methylbutanoate

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Technology Process of (2R)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-(aminomethyl)-2-benzyl-3-methylbutanoate

There total 4 articles about (2R)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-(aminomethyl)-2-benzyl-3-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 143100-08-7
(1S,2R,4R)-10-dicyclohexylsulfamoylisobornyl (S)-3-phenyl-2-isopropyl-2-cyanopropanoate

: 154520-28-2
(2R)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-(aminomethyl)-2-benzyl-3-methylbutanoate

Guidance literature:: With hydrogen; rhodium on alumina; In ethanol; ammonia; at 35 ℃; for 24h;
DOI:10.1021/jo00088a034

Reference yield:

: 98134-33-9
2-Cyano-3-methylbutanoyl chloride

: 154520-28-2
(2R)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-(aminomethyl)-2-benzyl-3-methylbutanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / AgCN / toluene / 4 h / 80 °C

2: 80 percent / LDA / 1.) THF, -78 deg C, 1 h, 2.) THF, HMPA, -78 deg C to r.t., r.t., 1 d

3: 84 percent / H₂ / 5percent Rh-Al₂O₃ / ethanol; NH₃ / 24 h / 35 °C

With silver cyanide; hydrogen; lithium diisopropyl amide; rhodium on alumina; In ethanol; ammonia; toluene;
DOI:10.1021/jo00088a034

Reference yield:

: 22426-27-3
2-Cyano-3-methylbutanoic acid

: 154520-28-2
(2R)-(1S,2R,4R)-10-(Dicyclohexylsulfamoyl)isobornyl 2-(aminomethyl)-2-benzyl-3-methylbutanoate

Guidance literature:: Multi-step reaction with 4 steps

1: PCl₅

2: 89 percent / AgCN / toluene / 4 h / 80 °C

3: 80 percent / LDA / 1.) THF, -78 deg C, 1 h, 2.) THF, HMPA, -78 deg C to r.t., r.t., 1 d

4: 84 percent / H₂ / 5percent Rh-Al₂O₃ / ethanol; NH₃ / 24 h / 35 °C

With silver cyanide; phosphorus pentachloride; hydrogen; lithium diisopropyl amide; rhodium on alumina; In ethanol; ammonia; toluene;
DOI:10.1021/jo00088a034