5-Bromo-2-(4-fluoro-phenyl)-3-(4-methanesulfonyl-2-methoxy-phenyl)-thiophene

Base Information

Chemical Name:5-Bromo-2-(4-fluoro-phenyl)-3-(4-methanesulfonyl-2-methoxy-phenyl)-thiophene
CAS No.:186690-24-4
Molecular Formula:C₁₈H₁₄BrFO₃S₂
Molecular Weight:441.342
Hs Code.:

Synonyms:5-Bromo-2-(4-fluoro-phenyl)-3-(4-methanesulfonyl-2-methoxy-phenyl)-thiophene

Suppliers and Price of 5-Bromo-2-(4-fluoro-phenyl)-3-(4-methanesulfonyl-2-methoxy-phenyl)-thiophene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-Bromo-2-(4-fluoro-phenyl)-3-(4-methanesulfonyl-2-methoxy-phenyl)-thiophene

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-Bromo-2-(4-fluoro-phenyl)-3-(4-methanesulfonyl-2-methoxy-phenyl)-thiophene

There total 7 articles about 5-Bromo-2-(4-fluoro-phenyl)-3-(4-methanesulfonyl-2-methoxy-phenyl)-thiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 186690-23-3
2-(4-Fluoro-phenyl)-3-(4-methanesulfonyl-2-methoxy-phenyl)-thiophene

: 186690-24-4
5-Bromo-2-(4-fluoro-phenyl)-3-(4-methanesulfonyl-2-methoxy-phenyl)-thiophene

Guidance literature:: With bromine; In dichloromethane; at 0 ℃; for 0.5h;

Reference yield:

: 15345-40-1
2-methoxy-4-(methylthio)benzaldehyde

: 186690-24-4
5-Bromo-2-(4-fluoro-phenyl)-3-(4-methanesulfonyl-2-methoxy-phenyl)-thiophene

Guidance literature:: Multi-step reaction with 6 steps

1: 73 percent / acetic anhydride, triethylamine / 19 h / Ambient temperature

2: 1.) diphenylphosphoryl azide, triethylamine, 2.) aq. H₂SO₄ / 1.) CH₂Cl₂, r.t., 24 h, 2.) CH₂Cl₂, MeOH, r.t., 12 h

3: 100 percent / phosphorus oxychloride / CHCl₃ / 12 h / 60 °C

4: 1.) triethylamine, 2.) copper powder, quinoline / 1.) 3-picoline, r.t., 1 h then 140 deg C, 2 h, 2.) 240 deg C, 4.5 h

5: 82 percent / sodium perborate tetrahydrate / acetic acid / 3 h / Ambient temperature

6: 83 percent / Br₂ / CH₂Cl₂ / 0.5 h / 0 °C

With quinoline; sodium perborate; sulfuric acid; diphenylphosphoranyl azide; bromine; acetic anhydride; copper; triethylamine; trichlorophosphate; In dichloromethane; chloroform; acetic acid;

Reference yield:

: 186690-19-7
1-(4-Fluoro-phenyl)-2-(2-methoxy-4-methylsulfanyl-phenyl)-ethanone

: 186690-24-4
5-Bromo-2-(4-fluoro-phenyl)-3-(4-methanesulfonyl-2-methoxy-phenyl)-thiophene

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / phosphorus oxychloride / CHCl₃ / 12 h / 60 °C

2: 1.) triethylamine, 2.) copper powder, quinoline / 1.) 3-picoline, r.t., 1 h then 140 deg C, 2 h, 2.) 240 deg C, 4.5 h

3: 82 percent / sodium perborate tetrahydrate / acetic acid / 3 h / Ambient temperature

4: 83 percent / Br₂ / CH₂Cl₂ / 0.5 h / 0 °C

With quinoline; sodium perborate; bromine; copper; triethylamine; trichlorophosphate; In dichloromethane; chloroform; acetic acid;