8-Azabicyclo[3.2.1]octan-2-one,6-ethyl-8-methyl-,(1R,5R)-rel-(9CI)

Base Information

• Chemical Name: 8-Azabicyclo[3.2.1]octan-2-one,6-ethyl-8-methyl-,(1R,5R)-rel-(9CI)
• CAS No.: 211517-32-7
• Molecular Formula: C₁₀H₁₇NO
• Molecular Weight: 167.251
• Mol file: 211517-32-7.mol

Synonyms:8-Azabicyclo[3.2.1]octan-2-one,6-ethyl-8-methyl-,(1R,5R)-rel-(9CI)

Chemical Property of 8-Azabicyclo[3.2.1]octan-2-one,6-ethyl-8-methyl-,(1R,5R)-rel-(9CI)

Chemical Property:

• Boiling Point: 240.6±23.0 °C(Predicted)
• PKA: 7.25±0.40(Predicted)
• Density: 0.995±0.06 g/cm3(Predicted)

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-Azabicyclo[3.2.1]octan-2-one,6-ethyl-8-methyl-,(1R,5R)-rel-(9CI)

There total 3 articles about 8-Azabicyclo[3.2.1]octan-2-one,6-ethyl-8-methyl-,(1R,5R)-rel-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

6-ethyl-8-methyl-8-azabicyclo[3.2.1]octan-2-one ethylene ketal → 6-ethyl-8-methyl-8-azabicyclo[3.2.1]octan-2-one (197588-51-5,211517-32-7)

Guidance literature:

With perchloric acid; at 90 ℃;

DOI:10.1002/jhet.5570340408

Reference yield:

6-exo-benzenesulfonyl-8-methyl-8-azabicyclo<3.2.1>octan-2-one ethylene ketal → 6-ethyl-8-methyl-8-azabicyclo[3.2.1]octan-2-one (197588-51-5,211517-32-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) n-BuLi / 1.) THF, from -78 to 0 deg C, 30 min, 2.) THF, a) 0 deg C, 3 h, b) from 0 to RT, 1 h

2: 91 percent / 40percent Na(Hg), Na₂HPO₄, MeOH / tetrahydrofuran

3: 72 percent / 3M HClO₄ / 90 °C

With methanol; disodium hydrogenphosphate; n-butyllithium; perchloric acid; sodium amalgam; In tetrahydrofuran;

DOI:10.1002/jhet.5570340408

Reference yield:

6-benzenesulfonyl-6-ethyl-8-methyl-8-azabicyclo[3.2.1]octan-2-one ethylene ketal → 6-ethyl-8-methyl-8-azabicyclo[3.2.1]octan-2-one (197588-51-5,211517-32-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / 40percent Na(Hg), Na₂HPO₄, MeOH / tetrahydrofuran

2: 72 percent / 3M HClO₄ / 90 °C

With methanol; disodium hydrogenphosphate; perchloric acid; sodium amalgam; In tetrahydrofuran;

DOI:10.1002/jhet.5570340408

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