tert-butyl 1-{9-[5-(1,2-dithiolan-3-yl)pentanamido]-2-[(ethoxycarbonyl)phenyl]-3-oxo-3H-xanthen-6-yloxy}-2-oxo-6,9,12-trioxa-3-azapentadecan-15-oate

Base Information

• Chemical Name: tert-butyl 1-{9-[5-(1,2-dithiolan-3-yl)pentanamido]-2-[(ethoxycarbonyl)phenyl]-3-oxo-3H-xanthen-6-yloxy}-2-oxo-6,9,12-trioxa-3-azapentadecan-15-oate
• CAS No.: 1357390-76-1
• Molecular Formula: C₄₅H₅₆N₂O₁₂S₂
• Molecular Weight: 881.078
• Mol file: 1357390-76-1.mol

Synonyms:tert-butyl 1-{9-[5-(1,2-dithiolan-3-yl)pentanamido]-2-[(ethoxycarbonyl)phenyl]-3-oxo-3H-xanthen-6-yloxy}-2-oxo-6,9,12-trioxa-3-azapentadecan-15-oate

Chemical Property of tert-butyl 1-{9-[5-(1,2-dithiolan-3-yl)pentanamido]-2-[(ethoxycarbonyl)phenyl]-3-oxo-3H-xanthen-6-yloxy}-2-oxo-6,9,12-trioxa-3-azapentadecan-15-oate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 1-{9-[5-(1,2-dithiolan-3-yl)pentanamido]-2-[(ethoxycarbonyl)phenyl]-3-oxo-3H-xanthen-6-yloxy}-2-oxo-6,9,12-trioxa-3-azapentadecan-15-oate

There total 5 articles about tert-butyl 1-{9-[5-(1,2-dithiolan-3-yl)pentanamido]-2-[(ethoxycarbonyl)phenyl]-3-oxo-3H-xanthen-6-yloxy}-2-oxo-6,9,12-trioxa-3-azapentadecan-15-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

tert-butyl 1-{[9-(5-amino-2-ethoxycarbonyl)phenyl]-3-oxo-3H-xanthen-6-yloxy}-2-oxo-6,9,12-trioxa-3-azapentadecan-15-oate (1357390-75-0) + Thioctic acid (1077-28-7,62-46-4) → tert-butyl 1-{9-[5-(1,2-dithiolan-3-yl)pentanamido]-2-[(ethoxycarbonyl)phenyl]-3-oxo-3H-xanthen-6-yloxy}-2-oxo-6,9,12-trioxa-3-azapentadecan-15-oate (1357390-76-1)

Guidance literature:

With diisopropyl-carbodiimide; In dichloromethane; at 20 ℃; for 48h;

DOI:10.1016/j.tet.2011.11.053

Reference yield:

4-amino-2-(6-tert-butoxycarbonylmethoxy-3-oxo-3H-xanthen-9-yl)-benzoic acid ethyl ester (886053-23-2) → tert-butyl 1-{9-[5-(1,2-dithiolan-3-yl)pentanamido]-2-[(ethoxycarbonyl)phenyl]-3-oxo-3H-xanthen-6-yloxy}-2-oxo-6,9,12-trioxa-3-azapentadecan-15-oate (1357390-76-1)

Guidance literature:

Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 23 h / 20 °C

3: diisopropyl-carbodiimide / dichloromethane / 48 h / 20 °C

With N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; diisopropyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.tet.2011.11.053

Reference yield:

4-amino-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-benzoic acid ethyl ester (219122-41-5) → tert-butyl 1-{9-[5-(1,2-dithiolan-3-yl)pentanamido]-2-[(ethoxycarbonyl)phenyl]-3-oxo-3H-xanthen-6-yloxy}-2-oxo-6,9,12-trioxa-3-azapentadecan-15-oate (1357390-76-1)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 23 h / 20 °C

4: diisopropyl-carbodiimide / dichloromethane / 48 h / 20 °C

With potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; diisopropyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.tet.2011.11.053

upstream raw materials:

4-amino-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-benzoic acid ethyl ester

4-amino-2-(6-tert-butoxycarbonylmethoxy-3-oxo-3H-xanthen-9-yl)-benzoic acid ethyl ester

2-{9-[5-amino-2-(ethoxycarbonyl)phenyl]-3-oxo-3H-xanthen-6-yloxy}aceticacid

tert-butyl 1-{[9-(5-amino-2-ethoxycarbonyl)phenyl]-3-oxo-3H-xanthen-6-yloxy}-2-oxo-6,9,12-trioxa-3-azapentadecan-15-oate