(4S,4aR,8aR)-4-(furan-3-yl)-3-methyl-8a-[(trimethylsilyl)oxy]-4a,5,6,7,8,8a-hexahydro-4H-1,2-benzoxazine 2-oxide

Base Information

Chemical Name:(4S,4aR,8aR)-4-(furan-3-yl)-3-methyl-8a-[(trimethylsilyl)oxy]-4a,5,6,7,8,8a-hexahydro-4H-1,2-benzoxazine 2-oxide
CAS No.:124070-89-9
Molecular Formula:C₁₆H₂₅NO₄Si
Molecular Weight:323.464
Hs Code.:
Mol file:124070-89-9.mol

Synonyms:4H-1,2-Benzoxazine,4-(3-furanyl)-4a,5,6,7,8,8a-hexahydro-3-methyl-8a-[(trimethylsilyl)oxy]-,2-oxide, (4a,4aa,8ab)- (9CI); 4H-1,2-Benzoxazine,4-(3-furanyl)-4a,5,6,7,8,8a-hexahydro-3-methyl-8a-[(trimethylsilyl)oxy]-,2-oxide, (4a,4aa,8ab)-(?à)-

Suppliers and Price of (4S,4aR,8aR)-4-(furan-3-yl)-3-methyl-8a-[(trimethylsilyl)oxy]-4a,5,6,7,8,8a-hexahydro-4H-1,2-benzoxazine 2-oxide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 2 raw suppliers

Chemical Property of (4S,4aR,8aR)-4-(furan-3-yl)-3-methyl-8a-[(trimethylsilyl)oxy]-4a,5,6,7,8,8a-hexahydro-4H-1,2-benzoxazine 2-oxide

Chemical Property:

Vapor Pressure:6.78E-06mmHg at 25°C
Boiling Point:388.6°Cat760mmHg
Flash Point:188.8°C
Density:1.11g/cm³

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (4S,4aR,8aR)-4-(furan-3-yl)-3-methyl-8a-[(trimethylsilyl)oxy]-4a,5,6,7,8,8a-hexahydro-4H-1,2-benzoxazine 2-oxide

There total 1 articles about (4S,4aR,8aR)-4-(furan-3-yl)-3-methyl-8a-[(trimethylsilyl)oxy]-4a,5,6,7,8,8a-hexahydro-4H-1,2-benzoxazine 2-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.2%

: 6651-36-1
1-(Trimethylsilyloxy)cyclohexene

: 124070-88-8,860003-90-3
(E)-1-(3-furyl)-2-nitro-1-propene

: 124070-89-9
4-(3-furyl)-3-methyl-8a-(trimethylsiloxy)-4a,5,6,7,8,8a-hexahydro-4H-benzoxazine N-oxide

: 124151-18-4
4-(3-furyl)-3-methyl-8a-(trimethylsiloxy)-4a,5,6,7,8,8a-hexahydro-4H-benzoxazine N-oxide

: 124151-17-3
4-(3-furyl)-3-methyl-8a-(trimethylsiloxy)-4a,5,6,7,8,8a-hexahydro-4H-benzoxazine N-oxide

Guidance literature:: With titanium(IV) isopropylate; titanium tetrachloride; In dichloromethane; -90 deg C, 90 min;
DOI:10.1021/jo00291a048

Reference yield:

: 124070-89-9
4-(3-furyl)-3-methyl-8a-(trimethylsiloxy)-4a,5,6,7,8,8a-hexahydro-4H-benzoxazine N-oxide

: 124070-90-2,124151-19-5,124151-20-8,124151-21-9
(1'RS,2SR)-2-<1'-(3-furyl)-2'-nitropropyl>cyclohexanone

Guidance literature:: With potassium fluoride; In methanol; for 5h; Ambient temperature;
DOI:10.1021/jo00291a048

Reference yield:

: 124070-89-9
4-(3-furyl)-3-methyl-8a-(trimethylsiloxy)-4a,5,6,7,8,8a-hexahydro-4H-benzoxazine N-oxide

: 124070-91-3
(R)-2-((S)-1-Furan-3-yl-2-oxo-propyl)-cyclohexanone

Guidance literature:: Multi-step reaction with 2 steps

1: KF / methanol / 5 h / Ambient temperature

2: 1.) t-BuOK 2.) t-BuOOH, VO(acac)2 / 1.) benzene, 9 deg C, 20 min 2.) 30 min

With tert.-butylhydroperoxide; potassium fluoride; bis(acetylacetonate)oxovanadium; potassium tert-butylate; In methanol;
DOI:10.1021/jo00291a048