1-(2-chloro-4-trifluoromethylphenyl)-3-(4-(4-((4-(2-hydrazinyl-2-oxoethyl)piperazin-1-yl)methyl)thiazol-2-yl)phenyl)urea

Base Information

Chemical Name:1-(2-chloro-4-trifluoromethylphenyl)-3-(4-(4-((4-(2-hydrazinyl-2-oxoethyl)piperazin-1-yl)methyl)thiazol-2-yl)phenyl)urea
CAS No.:1387637-19-5
Molecular Formula:C₂₄H₂₅ClF₃N₇O₂S
Molecular Weight:568.022
Hs Code.:

Synonyms:1-(2-chloro-4-trifluoromethylphenyl)-3-(4-(4-((4-(2-hydrazinyl-2-oxoethyl)piperazin-1-yl)methyl)thiazol-2-yl)phenyl)urea

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Chemical Property of 1-(2-chloro-4-trifluoromethylphenyl)-3-(4-(4-((4-(2-hydrazinyl-2-oxoethyl)piperazin-1-yl)methyl)thiazol-2-yl)phenyl)urea

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Technology Process of 1-(2-chloro-4-trifluoromethylphenyl)-3-(4-(4-((4-(2-hydrazinyl-2-oxoethyl)piperazin-1-yl)methyl)thiazol-2-yl)phenyl)urea

There total 7 articles about 1-(2-chloro-4-trifluoromethylphenyl)-3-(4-(4-((4-(2-hydrazinyl-2-oxoethyl)piperazin-1-yl)methyl)thiazol-2-yl)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.2%

: 1387637-13-9
C₂₆H₂₇ClF₃N₅O₃S

: 1387637-19-5
1-(2-chloro-4-trifluoromethylphenyl)-3-(4-(4-((4-(2-hydrazinyl-2-oxoethyl)piperazin-1-yl)methyl)thiazol-2-yl)phenyl)urea

Guidance literature:: With hydrazine hydrate; In ethanol; at 50 ℃; for 48h;
DOI:10.1248/cpb.c12-00234

Reference yield:

: 1387636-87-4
1-(2-chloro-4-trifluoromethylphenyl)-3-(4-cyanophenyl)urea

: 1387637-19-5
1-(2-chloro-4-trifluoromethylphenyl)-3-(4-(4-((4-(2-hydrazinyl-2-oxoethyl)piperazin-1-yl)methyl)thiazol-2-yl)phenyl)urea

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydrogensulfide; magnesium chloride / N,N-dimethyl-formamide

2: tetrahydrofuran / 7 h / 50 °C

3: ethanol / 2 h / 20 °C

4: potassium carbonate; sodium iodide / ethanol / 2 h / 50 °C

5: hydrazine hydrate / ethanol / 48 h / 50 °C

With sodium hydrogensulfide; hydrazine hydrate; potassium carbonate; sodium iodide; magnesium chloride; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.cclet.2012.06.009

Reference yield:

: 1387636-89-6
C₁₅H₁₁ClF₃N₃OS

: 1387637-19-5
1-(2-chloro-4-trifluoromethylphenyl)-3-(4-(4-((4-(2-hydrazinyl-2-oxoethyl)piperazin-1-yl)methyl)thiazol-2-yl)phenyl)urea

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 7 h / 50 °C

2: ethanol / 2 h / 20 °C

3: potassium carbonate; sodium iodide / ethanol / 2 h / 50 °C

4: hydrazine hydrate / ethanol / 48 h / 50 °C

With hydrazine hydrate; potassium carbonate; sodium iodide; In tetrahydrofuran; ethanol;
DOI:10.1016/j.cclet.2012.06.009