4-formyl(N-phenyl)pyrazole oxime

Base Information

• Chemical Name: 4-formyl(N-phenyl)pyrazole oxime
• CAS No.: 99185-49-6
• Molecular Formula: C₁₀H₉N₃O
• Molecular Weight: 187.201
• Mol file: 99185-49-6.mol

Synonyms:4-formyl(N-phenyl)pyrazole oxime

Chemical Property of 4-formyl(N-phenyl)pyrazole oxime

Chemical Property:

Purity/Quality:

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Technology Process of 4-formyl(N-phenyl)pyrazole oxime

There total 3 articles about 4-formyl(N-phenyl)pyrazole oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phenylhydrazine hydrochloride (59-88-1) → 4-formyl(N-phenyl)pyrazole oxime (99185-49-6)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride / ethanol / 2 h / 75 °C

2: trifluoroacetic acid / 12 h / 90 °C

3: hydroxylamine

With hydrogenchloride; hydroxylamine; trifluoroacetic acid; In ethanol; 2: |Duff Aldehyde Synthesis;

DOI:10.1007/s10787-020-00727-1

Reference yield:

1-phenyl-1H-pyrazole-4-carbaldehyde (54605-72-0) → 4-formyl(N-phenyl)pyrazole oxime (99185-49-6)

Guidance literature:

With hydroxylamine;

DOI:10.1016/S0040-4020(01)00340-4

Reference yield:

1-phenylpyrazole (1126-00-7) → 4-formyl(N-phenyl)pyrazole oxime (99185-49-6)

Guidance literature:

Multi-step reaction with 2 steps

1: POCl₃

2: NH₂OH

With hydroxylamine; trichlorophosphate; 1: Vilsmeier formylation;

DOI:10.1016/S0040-4020(01)00340-4

upstream raw materials:

1-phenyl-1H-pyrazole-4-carbaldehyde

1-phenylpyrazole

phenylhydrazine hydrochloride

Downstream raw materials:

5-(1-phenyl-1H-pyrazole-4-yl)-1H-tetrazole

1-phenyl-1H-pyrazole-4-carbonitrile

C₆₀CNOC₃H₂N₂C₆H₅