(1R,2R)-1-methyl-2-phenylcarbonyloxypropyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)-propanoate hydrochloride

Base Information

Chemical Name:(1R,2R)-1-methyl-2-phenylcarbonyloxypropyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)-propanoate hydrochloride
CAS No.:871580-42-6
Molecular Formula:C₂₀H₂₃NO₆*ClH
Molecular Weight:409.867
Hs Code.:

Synonyms:(1R,2R)-1-methyl-2-phenylcarbonyloxypropyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)-propanoate hydrochloride

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Chemical Property of (1R,2R)-1-methyl-2-phenylcarbonyloxypropyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)-propanoate hydrochloride

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Technology Process of (1R,2R)-1-methyl-2-phenylcarbonyloxypropyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)-propanoate hydrochloride

There total 2 articles about (1R,2R)-1-methyl-2-phenylcarbonyloxypropyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)-propanoate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 871580-96-0
(1R,2R)-1-methyl-2-phenylcarbonyloxypropyl (2S)-2-[(tert-butoxy)carbonylamino]-3-[3,4-bis(phenylmethoxy)phenyl]propanoate

: 871580-42-6
(1R,2R)-1-methyl-2-phenylcarbonyloxypropyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)-propanoate hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 2 h / 20 °C

2: hydrogenchloride / 1,4-dioxane / 0.5 h / 20 °C

With hydrogenchloride; hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol;

Reference yield:

: 871580-95-9
(1R,2R)-2-hydroxy-1-methylpropyl (2S)-2-[(tert-butoxy)carbonylamino]-3-[3,4-bis(phenylmethoxy)phenyl]propanoate

: 871580-42-6
(1R,2R)-1-methyl-2-phenylcarbonyloxypropyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)-propanoate hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: 2,4,6-trichlorobenzoyl chloride; triethylamine / dichloromethane / 0.5 h

1.2: 16 h / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 2 h / 20 °C

3.1: hydrogenchloride / 1,4-dioxane / 0.5 h / 20 °C

With hydrogenchloride; 2,4,6-trichlorobenzoyl chloride; hydrogen; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;

Reference yield: 97.0%

: 871580-42-6
(1R,2R)-1-methyl-2-phenylcarbonyloxypropyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)-propanoate hydrochloride

: 75-75-2,98527-29-8
methanesulfonic acid

: 1033891-36-9
(1R,2R)-1-methyl-2-phenylcarbonyloxypropyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate mesylate

Guidance literature:: (1R,2R)-1-methyl-2-phenylcarbonyloxypropyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)-propanoate hydrochloride; With water; sodium hydrogencarbonate; at 0 ℃;

methanesulfonic acid; In ethyl acetate; at 20 ℃;