2-((bis-tert-butoxycarbonyl)amino)-5-oxo-4-phenyl-5H-indeno[1,2-d]pyrimidine-8-carboxylic acid

Base Information

Chemical Name:2-((bis-tert-butoxycarbonyl)amino)-5-oxo-4-phenyl-5H-indeno[1,2-d]pyrimidine-8-carboxylic acid
CAS No.:1147077-79-9
Molecular Formula:C₂₈H₂₇N₃O₇
Molecular Weight:517.538
Hs Code.:

Synonyms:2-((bis-tert-butoxycarbonyl)amino)-5-oxo-4-phenyl-5H-indeno[1,2-d]pyrimidine-8-carboxylic acid

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Chemical Property of 2-((bis-tert-butoxycarbonyl)amino)-5-oxo-4-phenyl-5H-indeno[1,2-d]pyrimidine-8-carboxylic acid

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Technology Process of 2-((bis-tert-butoxycarbonyl)amino)-5-oxo-4-phenyl-5H-indeno[1,2-d]pyrimidine-8-carboxylic acid

There total 6 articles about 2-((bis-tert-butoxycarbonyl)amino)-5-oxo-4-phenyl-5H-indeno[1,2-d]pyrimidine-8-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1147077-80-2
C₂₈H₂₇N₃O₆

: 1147077-79-9
2-((bis-tert-butoxycarbonyl)amino)-5-oxo-4-phenyl-5H-indeno[1,2-d]pyrimidine-8-carboxylic acid

Guidance literature:: With potassium permanganate; In water; acetone; at 55 ℃; for 14h;
DOI:10.1021/jm201640m

Reference yield:

: 1147077-78-8
C₂₈H₂₈BrN₃O₅

: 1147077-79-9
2-((bis-tert-butoxycarbonyl)amino)-5-oxo-4-phenyl-5H-indeno[1,2-d]pyrimidine-8-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 4-methylmorpholine N-oxide / acetonitrile / 18 h / 20 °C / Molecular sieve

2: potassium permanganate / water; acetone / 14 h / 55 °C

With potassium permanganate; 4-methylmorpholine N-oxide; In water; acetone; acetonitrile;
DOI:10.1021/jm201640m

Reference yield:

: 1228035-28-6
2-amino-8-methyl-4-(methylthio)-5H-indeno[1,2-d]pyrimidin-5-one

: 1147077-79-9
2-((bis-tert-butoxycarbonyl)amino)-5-oxo-4-phenyl-5H-indeno[1,2-d]pyrimidine-8-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: dmap / N,N-dimethyl-formamide

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 80 °C

3: N-Bromosuccinimide; Phthalic acid dibutyl ester / benzene

4: 4-methylmorpholine N-oxide / acetonitrile / 18 h / 20 °C / Molecular sieve

5: potassium permanganate / water; acetone / 14 h / 55 °C

With dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium permanganate; N-Bromosuccinimide; Phthalic acid dibutyl ester; 4-methylmorpholine N-oxide; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetone; acetonitrile; benzene; 2: Suzuki coupling;
DOI:10.1021/jm201640m