3-Iodo-5-methylpyridin-2-amine

Base Information

• Chemical Name: 3-Iodo-5-methylpyridin-2-amine
• CAS No.: 211308-79-1
• Molecular Formula: C6H7 I N2
• Molecular Weight: 234.039
• Hs Code.: 2933399090
• European Community (EC) Number: 678-827-7
• DSSTox Substance ID: DTXSID20571848
• Nikkaji Number: J980.390D
• Wikidata: Q82460030
• Mol file: 211308-79-1.mol

Synonyms:3-Iodo-5-methylpyridin-2-amine;211308-79-1;2-Amino-3-iodo-5-methylpyridine;3-Iodo-5-methyl-pyridin-2-ylamine;2-Pyridinamine, 3-iodo-5-methyl-;MFCD09037445;6-Amino-5-iodo-3-picoline;SCHEMBL1311290;DTXSID20571848;GSRKHYYLAZKHSA-UHFFFAOYSA-N;AKOS015853936;AM86749;BS-2036;SB40518;SY041375;EN300-102563;I10161;3-Iodo-5-methyl-pyridin-2-ylamine, AldrichCPR;A879244

Chemical Property of 3-Iodo-5-methylpyridin-2-amine

Chemical Property:

• Vapor Pressure: 0.00152mmHg at 25°C
• Melting Point: 86-89°C
• Refractive Index: 1.674
• Boiling Point: 295.5°Cat760mmHg
• PKA: 4?+-.0.49(Predicted)
• Flash Point: 132.5°C
• PSA: 38.91000
• Density: 1.898g/cm³
• LogP: 2.15800
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Sensitive.: Light Sensitive
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 233.96540
• Heavy Atom Count: 9
• Complexity: 97.1

Purity/Quality:

97% ^*data from raw suppliers

2-Amino-3-iodo-5-methylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(N=C1)N)I

Technology Process of 3-Iodo-5-methylpyridin-2-amine

There total 1 articles about 3-Iodo-5-methylpyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

(5-methyl-pyridin-2-yl)amine (1603-41-4) → 2-amino-3-iodo-5-methylpyridine (211308-79-1)

Guidance literature:

With N-iodo-succinimide; trifluorormethanesulfonic acid; for 0.25h; Heating / reflux;

Reference yield: 79.0%

1-Phenyl-2-propyn-1-ol (4187-87-5) + 2-amino-3-iodo-5-methylpyridine (211308-79-1) → 6-methyl-2-phenyl-1,8-naphthyridine

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; at 150 ℃; for 0.5h; microwave irradiation;

DOI:10.1055/s-2008-1032067

Reference yield: 73.0%

methyl 4-ethynyl-3,5-difluorobenzoate + 2-amino-3-iodo-5-methylpyridine (211308-79-1) → C16H12F2N2O2

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; at 60 ℃; for 2h; Inert atmosphere;

upstream raw materials:

(5-methyl-pyridin-2-yl)amine

Downstream raw materials:

8-iodo-6-methyl-2-(4-fluorophenyl)imidazo[1,2-a]pyridine

5-methyl-3-[2-(trimethylsilyl)ethynyl]pyridin-2-ylamine

8-iodo-2-[4-(2-methoxy-phenyl)-piperazin-1-ylmethyl]-6-methyl-imidazo[1,2-a]pyridine

8-iodo-6-methylimidazo[1,2-a]pyridine