(S)-(4,5-dihydro-7H-thieno[2,3-c]pyran-7-yl)-N-methylmethanamine hydrochloride (R)-mandelate

Base Information

Chemical Name:(S)-(4,5-dihydro-7H-thieno[2,3-c]pyran-7-yl)-N-methylmethanamine hydrochloride (R)-mandelate
CAS No.:2374784-46-8
Molecular Formula:C₈H₈O₃*C₉H₁₃NOS
Molecular Weight:335.424
Hs Code.:

Synonyms:(S)-(4,5-dihydro-7H-thieno[2,3-c]pyran-7-yl)-N-methylmethanamine hydrochloride (R)-mandelate

Suppliers and Price of (S)-(4,5-dihydro-7H-thieno[2,3-c]pyran-7-yl)-N-methylmethanamine hydrochloride (R)-mandelate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-(4,5-dihydro-7H-thieno[2,3-c]pyran-7-yl)-N-methylmethanamine hydrochloride (R)-mandelate

Chemical Property:

Purity/Quality:: 99.9% ^*data from raw suppliers

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Technology Process of (S)-(4,5-dihydro-7H-thieno[2,3-c]pyran-7-yl)-N-methylmethanamine hydrochloride (R)-mandelate

There total 6 articles about (S)-(4,5-dihydro-7H-thieno[2,3-c]pyran-7-yl)-N-methylmethanamine hydrochloride (R)-mandelate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: TPMA

: 611-71-2
(R)-Mandelic Acid

: 2374784-46-8
(S)-(4,5-dihydro-7H-thieno[2,3-c]pyran-7-yl)-N-methylmethanamine hydrochloride (R)-mandelate

Guidance literature:: In acetone; acetonitrile; at 48 - 51 ℃;

Reference yield:

: 611-71-2
(R)-Mandelic Acid

: 2374784-45-7
1-(4,7-dihydro-5H-thieno[2,3-c]pyran-7-yl)-N-methylmethylamine trifluoromethanesulfonate

: 2374784-46-8
(S)-(4,5-dihydro-7H-thieno[2,3-c]pyran-7-yl)-N-methylmethanamine hydrochloride (R)-mandelate

Guidance literature:: 1-(4,7-dihydro-5H-thieno[2,3-c]pyran-7-yl)-N-methylmethylamine trifluoromethanesulfonate; With potassium hydroxide; In tert-butyl methyl ether; water; for 0.166667h; pH=>= 13;

(R)-Mandelic Acid; In acetone; acetonitrile; at 48 - 51 ℃; for 0.166667h;

Reference yield:

: 13781-67-4
3-(2-hydroxyethyl)thiophene

: 2374784-46-8
(S)-(4,5-dihydro-7H-thieno[2,3-c]pyran-7-yl)-N-methylmethanamine hydrochloride (R)-mandelate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 2-methyltetrahydrofuran / 0.08 h

1.2: 1 h / 80 °C

2.1: 2-methyltetrahydrofuran; toluene / 1.25 h / 40 - 50 °C

3.1: potassium hydroxide / tert-butyl methyl ether; water / 0.17 h / pH >= 13

3.2: 0.17 h / 48 - 51 °C

With potassium hydroxide; In 2-methyltetrahydrofuran; tert-butyl methyl ether; water; toluene;