(4RS)-7-[3-butenyl(phenylsulfonyl)amino]-4-hydroxymethyl-6-iodo-8-methoxy-1-phenylsulfonyl-2,3,4,5-tetrahydrobenzazepine

Base Information

Chemical Name:(4RS)-7-[3-butenyl(phenylsulfonyl)amino]-4-hydroxymethyl-6-iodo-8-methoxy-1-phenylsulfonyl-2,3,4,5-tetrahydrobenzazepine
CAS No.:608537-17-3
Molecular Formula:C₂₇H₂₉IN₂O₆S₂
Molecular Weight:668.574
Hs Code.:

Synonyms:(4RS)-7-[3-butenyl(phenylsulfonyl)amino]-4-hydroxymethyl-6-iodo-8-methoxy-1-phenylsulfonyl-2,3,4,5-tetrahydrobenzazepine

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Chemical Property of (4RS)-7-[3-butenyl(phenylsulfonyl)amino]-4-hydroxymethyl-6-iodo-8-methoxy-1-phenylsulfonyl-2,3,4,5-tetrahydrobenzazepine

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Technology Process of (4RS)-7-[3-butenyl(phenylsulfonyl)amino]-4-hydroxymethyl-6-iodo-8-methoxy-1-phenylsulfonyl-2,3,4,5-tetrahydrobenzazepine

There total 1 articles about (4RS)-7-[3-butenyl(phenylsulfonyl)amino]-4-hydroxymethyl-6-iodo-8-methoxy-1-phenylsulfonyl-2,3,4,5-tetrahydrobenzazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 608537-14-0
6-[3-butenyl(phenylsulfonyl)amino]-5-iodo-7-methoxy-4-methylene-1-phenylsulfonyl-1,2,3,4-tetrahydroquinoline

: 608537-17-3
(4RS)-7-[3-butenyl(phenylsulfonyl)amino]-4-hydroxymethyl-6-iodo-8-methoxy-1-phenylsulfonyl-2,3,4,5-tetrahydrobenzazepine

: 608537-16-2
(4RS)-6-[3-butenyl(phenylsulfonyl)amino]-4-hydroxymethyl-5-iodo-7-methoxy-1-phenylsulfonyl-1,2,3,4-tetrahydroquinoline

Guidance literature:: With water; silica gel; silver(l) oxide; In acetone; at 20 ℃; for 168h;
DOI:10.1002/ejoc.200300077

Reference yield: 96.0%

: 108-24-7
acetic anhydride

: 608537-17-3
(4RS)-7-[3-butenyl(phenylsulfonyl)amino]-4-hydroxymethyl-6-iodo-8-methoxy-1-phenylsulfonyl-2,3,4,5-tetrahydrobenzazepine

: (4RS)-4-acetoxymethyl-7-[3-butenyl(phenylsulfonyl)amino]-6-iodo-8-methoxy-1-phenylsulfonyl-2,3,4,5-tetrahydrobenzazepine

Guidance literature:: With sodium acetate; at 60 ℃; for 1h;
DOI:10.1002/ejoc.200300077

Reference yield:

: 608537-17-3
(4RS)-7-[3-butenyl(phenylsulfonyl)amino]-4-hydroxymethyl-6-iodo-8-methoxy-1-phenylsulfonyl-2,3,4,5-tetrahydrobenzazepine

: (2RS)-2-acetoxy-7-methoxy-11-methylene-5,8-bis(phenylsulfonyl)-1,2,3,4,8,9,10,11-octahydroazepino[3,2-f]quinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / sodium acetate / 1 h / 60 °C

2: 84 percent / palladium acetate; triphenylphosphane; silver carbonate / dimethylformamide / 20 h / 60 °C

With sodium acetate; palladium diacetate; triphenylphosphine; silver carbonate; In N,N-dimethyl-formamide;
DOI:10.1002/ejoc.200300077