di(t-butyl) p--N-2-propynylamino>benzoyl-γ-<α-(3-methoxycarbonylpropylamino)>glutamyl-glutamate

Base Information

Chemical Name:di(t-butyl) p--N-2-propynylamino>benzoyl-γ-<α-(3-methoxycarbonylpropylamino)>glutamyl-glutamate
CAS No.:120092-32-2
Molecular Formula:C₄₂H₅₅N₇O₁₀
Molecular Weight:817.94
Hs Code.:

di(t-butyl) p-<N-<(2-amino-4-hydroxy-6-quinazolinyl)methyl>-N-2-propynylamino>benzoyl-γ-<α-(3-methoxycarbonylpropylamino)>glutamyl-glutamate

Synonyms:di(t-butyl) p--N-2-propynylamino>benzoyl-γ-<α-(3-methoxycarbonylpropylamino)>glutamyl-glutamate

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Chemical Property of di(t-butyl) p--N-2-propynylamino>benzoyl-γ-<α-(3-methoxycarbonylpropylamino)>glutamyl-glutamate

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Technology Process of di(t-butyl) p--N-2-propynylamino>benzoyl-γ-<α-(3-methoxycarbonylpropylamino)>glutamyl-glutamate

There total 9 articles about di(t-butyl) p--N-2-propynylamino>benzoyl-γ-<α-(3-methoxycarbonylpropylamino)>glutamyl-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 77766-62-2
2-amino-6-bromomethyl-4-hydroxyquinazoline hydrobromide

: 120092-08-2
di(t-butyl) p-N-2-propynylaminobenzoyl-γ-<α-(3-methoxycarbonylpropylamino)>glutamyl glutamate

: 120092-32-2
di(t-butyl) p--N-2-propynylamino>benzoyl-γ-<α-(3-methoxycarbonylpropylamino)>glutamyl-glutamate

Guidance literature:: With calcium carbonate; In N,N-dimethyl acetamide; at 25 - 27 ℃; for 168h;

Reference yield:

: 3886-08-6
5-tert-butyl N-benzyloxycarbonyl-L-glutamate

: 120092-32-2
di(t-butyl) p--N-2-propynylamino>benzoyl-γ-<α-(3-methoxycarbonylpropylamino)>glutamyl-glutamate

Guidance literature:: Multi-step reaction with 8 steps

1: 1. N-methylmorpholine, isobutyl chlorocarbonate; 2. N-methylmorpholine / 1. THF, -20 deg C, 4 min; 2. 45 min, -10 to 10 deg C

2: 90 percent / H₂ / Pd/C / methanol / 2.5 h / 21 °C

3: 66 percent / tributylamine / dioxane / 0.33 h

4: 78 percent / CF₃COOH / 0.25 h

5: 1. N-methylmorpholine, isobutyl chlorocarbonate; 2. N-methylmorpholine / 1. DMF, -15 deg C, 4 min; 2. 45 min, -10 to 10 deg C

6: H₂ / Pd/C / methanol / 0.33 h / 21 °C

7: CaCO₃ / N,N-dimethyl-acetamide / 165 h / 21 - 22 °C

8: 55 percent / CaCO₃ / N,N-dimethyl-acetamide / 168 h / 25 - 27 °C

With 4-methyl-morpholine; tributyl-amine; hydrogen; trifluoroacetic acid; calcium carbonate; isobutyl chloroformate; palladium on activated charcoal; In 1,4-dioxane; methanol; N,N-dimethyl acetamide;

Reference yield:

: 13031-60-2
methyl γ-aminobutyrate hydrochloride

: 120092-32-2
di(t-butyl) p--N-2-propynylamino>benzoyl-γ-<α-(3-methoxycarbonylpropylamino)>glutamyl-glutamate

Guidance literature:: Multi-step reaction with 8 steps

1: 1. N-methylmorpholine, isobutyl chlorocarbonate; 2. N-methylmorpholine / 1. THF, -20 deg C, 4 min; 2. 45 min, -10 to 10 deg C

2: 90 percent / H₂ / Pd/C / methanol / 2.5 h / 21 °C

3: 66 percent / tributylamine / dioxane / 0.33 h

4: 78 percent / CF₃COOH / 0.25 h

5: 1. N-methylmorpholine, isobutyl chlorocarbonate; 2. N-methylmorpholine / 1. DMF, -15 deg C, 4 min; 2. 45 min, -10 to 10 deg C

6: H₂ / Pd/C / methanol / 0.33 h / 21 °C

7: CaCO₃ / N,N-dimethyl-acetamide / 165 h / 21 - 22 °C

8: 55 percent / CaCO₃ / N,N-dimethyl-acetamide / 168 h / 25 - 27 °C

With 4-methyl-morpholine; tributyl-amine; hydrogen; trifluoroacetic acid; calcium carbonate; isobutyl chloroformate; palladium on activated charcoal; In 1,4-dioxane; methanol; N,N-dimethyl acetamide;