(1R,2S)-2-((1,3-dimethyl-6-oxo-1,6-dihydropyridazin-4-yl)oxymethyl)-2-phenylcyclopropanecarbaldehyde

Base Information

Chemical Name:(1R,2S)-2-((1,3-dimethyl-6-oxo-1,6-dihydropyridazin-4-yl)oxymethyl)-2-phenylcyclopropanecarbaldehyde
CAS No.:1383747-29-2
Molecular Formula:C₁₇H₁₈N₂O₃
Molecular Weight:298.342
Hs Code.:

Synonyms:(1R,2S)-2-((1,3-dimethyl-6-oxo-1,6-dihydropyridazin-4-yl)oxymethyl)-2-phenylcyclopropanecarbaldehyde

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Chemical Property of (1R,2S)-2-((1,3-dimethyl-6-oxo-1,6-dihydropyridazin-4-yl)oxymethyl)-2-phenylcyclopropanecarbaldehyde

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Technology Process of (1R,2S)-2-((1,3-dimethyl-6-oxo-1,6-dihydropyridazin-4-yl)oxymethyl)-2-phenylcyclopropanecarbaldehyde

There total 7 articles about (1R,2S)-2-((1,3-dimethyl-6-oxo-1,6-dihydropyridazin-4-yl)oxymethyl)-2-phenylcyclopropanecarbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383747-28-1
5-{[(1S,2R)-2-Hydroxymethyl-1-phenylcyclopropyl]methoxy}-2,6-dimethyl-2H-pyridazin-3-one

: 1383747-29-2
(1R,2S)-2-((1,3-dimethyl-6-oxo-1,6-dihydropyridazin-4-yl)oxymethyl)-2-phenylcyclopropanecarbaldehyde

Guidance literature:: 5-{[(1S,2R)-2-Hydroxymethyl-1-phenylcyclopropyl]methoxy}-2,6-dimethyl-2H-pyridazin-3-one; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 0.5h;

With triethylamine; In dichloromethane; at 10 - 35 ℃; for 1h;

Reference yield:

: 763126-74-5
(1R,2S)-1,2-di(hydroxymethyl)-2-phenylcyclopropane

: 1383747-29-2
(1R,2S)-2-((1,3-dimethyl-6-oxo-1,6-dihydropyridazin-4-yl)oxymethyl)-2-phenylcyclopropanecarbaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 1 h / -15 °C

2.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1.5 h / 0 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 1.5 h / 80 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 - 35 °C

5.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C

5.2: 1 h / 10 - 35 °C

With 1H-imidazole; oxalyl dichloride; carbon tetrabromide; tetrabutyl ammonium fluoride; potassium carbonate; dimethyl sulfoxide; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 5.1: Swern Oxidation;

Reference yield:

: (1S,2R)-2-(tert-butyldiphenylsilyloxymethyl)-1-phenylcyclopropylmethanol

: 1383747-29-2
(1R,2S)-2-((1,3-dimethyl-6-oxo-1,6-dihydropyridazin-4-yl)oxymethyl)-2-phenylcyclopropanecarbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1.5 h / 0 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 1.5 h / 80 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 - 35 °C

4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C

4.2: 1 h / 10 - 35 °C

With oxalyl dichloride; carbon tetrabromide; tetrabutyl ammonium fluoride; potassium carbonate; dimethyl sulfoxide; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 4.1: Swern Oxidation;