Technology Process of methyl 1β-dimethylphenylsilyl-7α,12α-diacetoxy-3-oxo-5β-cholan-24-oate
There total 8 articles about methyl 1β-dimethylphenylsilyl-7α,12α-diacetoxy-3-oxo-5β-cholan-24-oate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
phenyldimethylsilyl chloride;
With
copper(l) iodide; lithium;
In
tetrahydrofuran;
at -30 - 0 ℃;
for 1.5h;
methyl 7α,12α-diacetoxy-3-oxo-5β-chol-1-en-24-oate;
In
tetrahydrofuran;
at -30 ℃;
for 0.5h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: acetic acid; bromine / chloroform / 1 h / 20 °C
2.1: lithium carbonate; lithium bromide / N,N-dimethyl-formamide / 8 h / 80 °C / Inert atmosphere
3.1: acetic acid; zinc / 0.5 h / 20 °C
4.1: lithium; copper(l) iodide / tetrahydrofuran / 1.5 h / -30 - 0 °C
4.2: 0.5 h / -30 °C
With
copper(l) iodide; bromine; lithium; lithium carbonate; acetic acid; lithium bromide; zinc;
In
tetrahydrofuran; chloroform; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: silver carbonate / toluene / 9 h / 150 °C
2.1: pyridine; dmap / 1 h / 20 °C
3.1: acetic acid; bromine / chloroform / 1 h / 20 °C
4.1: lithium carbonate; lithium bromide / N,N-dimethyl-formamide / 8 h / 80 °C / Inert atmosphere
5.1: acetic acid; zinc / 0.5 h / 20 °C
6.1: lithium; copper(l) iodide / tetrahydrofuran / 1.5 h / -30 - 0 °C
6.2: 0.5 h / -30 °C
With
pyridine; dmap; copper(l) iodide; bromine; lithium; lithium carbonate; acetic acid; silver carbonate; lithium bromide; zinc;
In
tetrahydrofuran; chloroform; N,N-dimethyl-formamide; toluene;
