(2R,4S)-Methyl 4-<(S)-2-(2,2-dimethoxyethyl)-α-hydroxybenzyl>-2-(1,1-dimethylethyl)-3-oxazolidincarboxylat

Base Information

Chemical Name:(2R,4S)-Methyl 4-<(S)-2-(2,2-dimethoxyethyl)-α-hydroxybenzyl>-2-(1,1-dimethylethyl)-3-oxazolidincarboxylat
CAS No.:148919-58-8
Molecular Formula:C₂₀H₃₁NO₆
Molecular Weight:381.469
Hs Code.:

Synonyms:(2R,4S)-Methyl 4-<(S)-2-(2,2-dimethoxyethyl)-α-hydroxybenzyl>-2-(1,1-dimethylethyl)-3-oxazolidincarboxylat

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Chemical Property of (2R,4S)-Methyl 4-<(S)-2-(2,2-dimethoxyethyl)-α-hydroxybenzyl>-2-(1,1-dimethylethyl)-3-oxazolidincarboxylat

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Technology Process of (2R,4S)-Methyl 4-<(S)-2-(2,2-dimethoxyethyl)-α-hydroxybenzyl>-2-(1,1-dimethylethyl)-3-oxazolidincarboxylat

There total 3 articles about (2R,4S)-Methyl 4-<(S)-2-(2,2-dimethoxyethyl)-α-hydroxybenzyl>-2-(1,1-dimethylethyl)-3-oxazolidincarboxylat which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 148919-59-9
(2R,4S)-(-)-Methyl 4-<2-(2,2-dimethoxyethyl)benzoyl>-2-(1,1-dimethylethyl)-3-oxazolidincarboxylat

: 148919-57-7
(2R,4S)-(+)-Methyl 4-<(R)-2-(2,2-dimethoxyethyl)-α-hydroxybenzyl>-2-(1,1-dimethylethyl)-3-oxazolidincarboxylat

: 148919-58-8
(2R,4S)-Methyl 4-<(S)-2-(2,2-dimethoxyethyl)-α-hydroxybenzyl>-2-(1,1-dimethylethyl)-3-oxazolidincarboxylat

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; at -78 ℃; for 4h; Yields of byproduct given;
DOI:10.1002/ardp.19933260208

Reference yield:

: (2R,4S)-Methyl 4-<2-(2,2-dimethoxyethyl)-α-hydroxybenzyl>-2-(1,1-dimethylethyl)-3-oxazolidincarboxylat

: 148919-58-8
(2R,4S)-Methyl 4-<(S)-2-(2,2-dimethoxyethyl)-α-hydroxybenzyl>-2-(1,1-dimethylethyl)-3-oxazolidincarboxylat

Guidance literature:: Multi-step reaction with 2 steps

1: 1) (COCl)2, DMSO, 2) Et₃N / 1) CH₂Cl₂, 15 min, -65 to -60 deg C, 2) a) 5 min, -60 deg C, b) 10 min, r.t.

2: 72 percent / LiAlH₄ / tetrahydrofuran; diethyl ether / 4 h / -78 °C

With lithium aluminium tetrahydride; oxalyl dichloride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; diethyl ether;
DOI:10.1002/ardp.19933260208

Reference yield:

: 112396-13-1
2-(2-bromophenyl)acetaldehyde dimethyl acetal

: 148919-45-3
(2R,4S)-(-)-Methyl-2-(1,1-dimethylethyl)-4-formyl-3-oxazolidincarboxylat

: 148919-57-7
(2R,4S)-(+)-Methyl 4-<(R)-2-(2,2-dimethoxyethyl)-α-hydroxybenzyl>-2-(1,1-dimethylethyl)-3-oxazolidincarboxylat

: 148919-58-8
(2R,4S)-Methyl 4-<(S)-2-(2,2-dimethoxyethyl)-α-hydroxybenzyl>-2-(1,1-dimethylethyl)-3-oxazolidincarboxylat

Guidance literature:: With n-butyllithium; Yield given. Multistep reaction. Yields of byproduct given; 1) THF, hexane, 30 min, -78 deg C, 2) THF, a) 5 h, -78 deg C, b) 20 min, r.t.;
DOI:10.1002/ardp.19933260208