1-(2-azidophenyl)-3-(4-fluorophenyl)prop-2-yn-1-yl methyl carbonate

Base Information

• Chemical Name: 1-(2-azidophenyl)-3-(4-fluorophenyl)prop-2-yn-1-yl methyl carbonate
• CAS No.: 1453188-92-5
• Molecular Formula: C₁₇H₁₂FN₃O₃
• Molecular Weight: 325.299
• Mol file: 1453188-92-5.mol

Synonyms:1-(2-azidophenyl)-3-(4-fluorophenyl)prop-2-yn-1-yl methyl carbonate

Chemical Property of 1-(2-azidophenyl)-3-(4-fluorophenyl)prop-2-yn-1-yl methyl carbonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-azidophenyl)-3-(4-fluorophenyl)prop-2-yn-1-yl methyl carbonate

There total 2 articles about 1-(2-azidophenyl)-3-(4-fluorophenyl)prop-2-yn-1-yl methyl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C15H10FN3O + methyl chloroformate (79-22-1) → 1-(2-azidophenyl)-3-(4-fluorophenyl)prop-2-yn-1-yl methyl carbonate (1453188-92-5)

Guidance literature:

With pyridine; dmap; In dichloromethane; at 0 - 20 ℃; for 3h; Inert atmosphere;

DOI:10.1021/jo401324k

Reference yield:

1-(2-azidophenyl)prop-2-yn-1-ol → 1-(2-azidophenyl)-3-(4-fluorophenyl)prop-2-yn-1-yl methyl carbonate (1453188-92-5)

Guidance literature:

Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 1 h / 20 °C / Schlenk technique; Sealed tube; Inert atmosphere

2: pyridine; dmap / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

With pyridine; dmap; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo401324k

Reference yield: 53.0%

1-(2-azidophenyl)-3-(4-fluorophenyl)prop-2-yn-1-yl methyl carbonate (1453188-92-5) → 2-(4-fluorophenyl)quinolin-4-yl methyl carbonate (1453188-74-3)

Guidance literature:

With (triphenylphosphine)gold(I) chloride; silver perchlorate; In 1,2-dichloro-ethane; at 60 ℃; for 72h; Schlenk technique; Inert atmosphere;

DOI:10.1021/jo401324k

upstream raw materials:

methyl chloroformate

Downstream raw materials:

2-(4-fluorophenyl)quinolin-4-yl methyl carbonate