(Z)-2-Cyano-3-{4-[(E)-2-(4-dimethylamino-phenyl)-vinyl]-phenyl}-acrylamide

Base Information

• Chemical Name: (Z)-2-Cyano-3-{4-[(E)-2-(4-dimethylamino-phenyl)-vinyl]-phenyl}-acrylamide
• CAS No.: 77530-16-6
• Molecular Formula: C₂₀H₁₉N₃O
• Molecular Weight: 317.39
• Mol file: 77530-16-6.mol

Synonyms:(Z)-2-Cyano-3-{4-[(E)-2-(4-dimethylamino-phenyl)-vinyl]-phenyl}-acrylamide

Chemical Property of (Z)-2-Cyano-3-{4-[(E)-2-(4-dimethylamino-phenyl)-vinyl]-phenyl}-acrylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-2-Cyano-3-{4-[(E)-2-(4-dimethylamino-phenyl)-vinyl]-phenyl}-acrylamide

There total 4 articles about (Z)-2-Cyano-3-{4-[(E)-2-(4-dimethylamino-phenyl)-vinyl]-phenyl}-acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4-[2-(4-dimethylaminophenyl)vinyl]benzaldehyde (26198-05-0) + cyanoacetic acid amide (107-91-5) → (Z)-2-Cyano-3-{4-[(E)-2-(4-dimethylamino-phenyl)-vinyl]-phenyl}-acrylamide (77530-16-6)

Guidance literature:

piperidine; In ethanol; for 2h; Heating;

Reference yield:

Triphenyl-<4-(1,3-dioxolanyl-(2)-benzyl>-phosphoniumchlorid (26104-71-2) → (Z)-2-Cyano-3-{4-[(E)-2-(4-dimethylamino-phenyl)-vinyl]-phenyl}-acrylamide (77530-16-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 34 percent / sodium methoxide / methanol / overnight

2: CH₃COOH

3: 87 percent / piperidine / ethanol / 2 h / Heating

With sodium methylate; acetic acid; piperidine; In methanol; ethanol;

Reference yield:

4'-(dimethylamino)-4-stilbenecarboxaldehyde ethylene acetal (77530-23-5) → (Z)-2-Cyano-3-{4-[(E)-2-(4-dimethylamino-phenyl)-vinyl]-phenyl}-acrylamide (77530-16-6)

Guidance literature:

Multi-step reaction with 2 steps

1: CH₃COOH

2: 87 percent / piperidine / ethanol / 2 h / Heating

With acetic acid; piperidine; In ethanol;

upstream raw materials:

4-[2-(4-dimethylaminophenyl)vinyl]benzaldehyde

cyanoacetic acid amide

Triphenyl-<4-(1,3-dioxolanyl-(2)-benzyl>-phosphoniumchlorid

4'-(dimethylamino)-4-stilbenecarboxaldehyde ethylene acetal