3-(1-methoxy-8-methyl-3-phenyl-1H-pyrano[4,3-b]quinolin-4-yl)-acrylic acid tert-butyl ester

Base Information

Chemical Name:3-(1-methoxy-8-methyl-3-phenyl-1H-pyrano[4,3-b]quinolin-4-yl)-acrylic acid tert-butyl ester
CAS No.:1263317-07-2
Molecular Formula:C₂₇H₂₇NO₄
Molecular Weight:429.516
Hs Code.:

Synonyms:3-(1-methoxy-8-methyl-3-phenyl-1H-pyrano[4,3-b]quinolin-4-yl)-acrylic acid tert-butyl ester

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Chemical Property of 3-(1-methoxy-8-methyl-3-phenyl-1H-pyrano[4,3-b]quinolin-4-yl)-acrylic acid tert-butyl ester

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Technology Process of 3-(1-methoxy-8-methyl-3-phenyl-1H-pyrano[4,3-b]quinolin-4-yl)-acrylic acid tert-butyl ester

There total 4 articles about 3-(1-methoxy-8-methyl-3-phenyl-1H-pyrano[4,3-b]quinolin-4-yl)-acrylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1663-39-4,25232-27-3
tert-Butyl acrylate

: 1263316-91-1
4-iodo-1-methoxy-8-methyl-3-phenyl-1H-pyrano[4,3-b]quinoline

: 1263317-07-2
3-(1-methoxy-8-methyl-3-phenyl-1H-pyrano[4,3-b]quinolin-4-yl)-acrylic acid tert-butyl ester

Guidance literature:: With triethylamine; triphenylphosphine; palladium dichloride; In acetonitrile; at 80 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.tet.2010.10.081

Reference yield:

: 73568-27-1
2-chloro-6-methylquinoline-3-carbaldehyde

: 1263317-07-2
3-(1-methoxy-8-methyl-3-phenyl-1H-pyrano[4,3-b]quinolin-4-yl)-acrylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; triphenylphosphine; palladium dichloride / acetonitrile / 80 °C

2: N-iodo-succinimide / 0.08 h / 20 °C

3: triethylamine; triphenylphosphine; palladium dichloride / acetonitrile / 2 h / 80 °C / Inert atmosphere

With N-iodo-succinimide; triethylamine; triphenylphosphine; palladium dichloride; In acetonitrile; 1: Sonogashira coupling / 3: Heck reaction;
DOI:10.1016/j.tet.2010.10.081

Reference yield:

: 536-74-3
phenylacetylene

: 1263317-07-2
3-(1-methoxy-8-methyl-3-phenyl-1H-pyrano[4,3-b]quinolin-4-yl)-acrylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; triphenylphosphine; palladium dichloride / acetonitrile / 80 °C

2: N-iodo-succinimide / 0.08 h / 20 °C

3: triethylamine; triphenylphosphine; palladium dichloride / acetonitrile / 2 h / 80 °C / Inert atmosphere

With N-iodo-succinimide; triethylamine; triphenylphosphine; palladium dichloride; In acetonitrile; 1: Sonogashira coupling / 3: Heck reaction;
DOI:10.1016/j.tet.2010.10.081