PYR-PHE-OH

Base Information

• Chemical Name: PYR-PHE-OH
• CAS No.: 21282-12-2
• Molecular Formula: C14H16 N2 O4
• Molecular Weight: 276.292
• Hs Code.: 2933790090
• Mol file: 21282-12-2.mol

Synonyms:Alanine,N-(5-oxo-L-prolyl)-3-phenyl-, L- (8CI); L-Phenylalanine, N-(5-oxo-L-prolyl)-;Pyro-L-glutamylphenylalanine; Pyroglutamyl-L-phenylalanine

Chemical Property of PYR-PHE-OH

Chemical Property:

• PSA: 95.50000
• LogP: 0.79680
• Storage Temp.: -15°C

Purity/Quality:

99% ^*data from raw suppliers

PYR-PHE-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of PYR-PHE-OH

There total 1 articles about PYR-PHE-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

Boc-pGlu-Phe-Ot-Bu → L-pyroglutamyl-L-phenylalanine (21282-12-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 3h;

DOI:10.1016/j.lfs.2014.08.017

Reference yield: 80.0%

L-pyroglutamyl-L-phenylalanine (21282-12-2) + (4-hydroxyphenyl)(methyl)(benzyl)sulfonium chloride → (S)-2-[((S)-5-Oxo-pyrrolidine-2-carbonyl)-amino]-3-phenyl-propionic acid benzyl ester

Guidance literature:

With potassium carbonate; In dichloromethane; for 8h; Ambient temperature;

DOI:10.1246/bcsj.69.1099

Reference yield: 27.0%

methyl 5-amino-4-oxo-6-phenylhexanoate hydrochloride (100242-07-7) + L-pyroglutamyl-L-phenylalanine (21282-12-2) → pGlu-Phe-(RS)-Pheψ(COCH2)Gly-OMe

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;

DOI:10.1021/jm00397a026

Downstream raw materials:

L-pyroglutamyl-L-phenylalanylcyanamide