2,5-bis(5-bromothiophen-2-yl)-1-(2,6-diisopropylphenyl)-1Hpyrrole-3-carbaldehyde

Base Information

Chemical Name:2,5-bis(5-bromothiophen-2-yl)-1-(2,6-diisopropylphenyl)-1Hpyrrole-3-carbaldehyde
CAS No.:1384262-14-9
Molecular Formula:C₂₅H₂₃Br₂NOS₂
Molecular Weight:577.404
Hs Code.:

Synonyms:2,5-bis(5-bromothiophen-2-yl)-1-(2,6-diisopropylphenyl)-1Hpyrrole-3-carbaldehyde

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Chemical Property of 2,5-bis(5-bromothiophen-2-yl)-1-(2,6-diisopropylphenyl)-1Hpyrrole-3-carbaldehyde

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Technology Process of 2,5-bis(5-bromothiophen-2-yl)-1-(2,6-diisopropylphenyl)-1Hpyrrole-3-carbaldehyde

There total 2 articles about 2,5-bis(5-bromothiophen-2-yl)-1-(2,6-diisopropylphenyl)-1Hpyrrole-3-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1236309-07-1
2,5-bis(5-bromothiophen-2-yl)-1-(2,6-diisopropylphenyl)-1H-pyrrole

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 1384262-14-9
2,5-bis(5-bromothiophen-2-yl)-1-(2,6-diisopropylphenyl)-1Hpyrrole-3-carbaldehyde

Guidance literature:: N,N-dimethyl-formamide; With trichlorophosphate; In dichloromethane; at 0 ℃; for 0.5h; Reflux;

2,5-bis(5-bromothiophen-2-yl)-1-(2,6-diisopropylphenyl)-1H-pyrrole; In dichloromethane; at 0 ℃; for 2h; Reflux;

With water; sodium acetate; In dichloromethane; for 1h; Reflux;
DOI:10.1016/j.tet.2012.04.104

Reference yield:

: 1236309-06-0
1-(2,6-diisopropylphenyl)-2,5-di(thiophen-2-yl)-1H-pyrrole

: 1384262-14-9
2,5-bis(5-bromothiophen-2-yl)-1-(2,6-diisopropylphenyl)-1Hpyrrole-3-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 6 h / 0 °C

2.1: trichlorophosphate / dichloromethane / 0.5 h / 0 °C / Reflux

2.2: 2 h / 0 °C / Reflux

2.3: 1 h / Reflux

With N-Bromosuccinimide; trichlorophosphate; In dichloromethane; N,N-dimethyl-formamide; 2.1: Vilsmeier formylation / 2.2: Vilsmeier formylation / 2.3: Vilsmeier formylation;
DOI:10.1016/j.tet.2012.04.104

Reference yield: 75.0%

: 1384262-14-9
2,5-bis(5-bromothiophen-2-yl)-1-(2,6-diisopropylphenyl)-1Hpyrrole-3-carbaldehyde

: 201802-67-7
4-(diphenylamino)phenyl boronic acid

: 1384262-15-0
2,5-bis(5-(4-(diphenylamino)phenyl)thiophen-2-yl)-1-(2,6-diisopropylphenyl)-1H-pyrrole-3-carbaldehyde

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In tetrahydrofuran; water; for 48h; Inert atmosphere; Reflux;
DOI:10.1016/j.tet.2012.04.104