N-{[4-(5,5-dimethyl-1,3-dioxan-2-yl)-1-naphthyl]methyl}-(S)-phenylalaninamide

Base Information

Chemical Name:N-{[4-(5,5-dimethyl-1,3-dioxan-2-yl)-1-naphthyl]methyl}-(S)-phenylalaninamide
CAS No.:490038-29-4
Molecular Formula:C₂₆H₃₀N₂O₃
Molecular Weight:418.536
Hs Code.:

Synonyms:N-{[4-(5,5-dimethyl-1,3-dioxan-2-yl)-1-naphthyl]methyl}-(S)-phenylalaninamide

Suppliers and Price of N-{[4-(5,5-dimethyl-1,3-dioxan-2-yl)-1-naphthyl]methyl}-(S)-phenylalaninamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of N-{[4-(5,5-dimethyl-1,3-dioxan-2-yl)-1-naphthyl]methyl}-(S)-phenylalaninamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Hazard Codes:

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Technology Process of N-{[4-(5,5-dimethyl-1,3-dioxan-2-yl)-1-naphthyl]methyl}-(S)-phenylalaninamide

There total 4 articles about N-{[4-(5,5-dimethyl-1,3-dioxan-2-yl)-1-naphthyl]methyl}-(S)-phenylalaninamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 65864-22-4
(S)-2-amino-3-phenylpropionamide hydrochloride

: 490038-28-3
2-[4-(bromomethyl)-1-naphthyl]-5,5-dimethyl-1,3-dioxane

: 490038-29-4
N-{[4-(5,5-dimethyl-1,3-dioxan-2-yl)-1-naphthyl]methyl}-(S)-phenylalaninamide

Guidance literature:: With sodium hydrogencarbonate; In acetonitrile; for 48h; Heating;
DOI:10.1021/jm0208572

Reference yield:

: 57322-45-9
1,4-dihydroxymethyl naphthalene

: 490038-29-4
N-{[4-(5,5-dimethyl-1,3-dioxan-2-yl)-1-naphthyl]methyl}-(S)-phenylalaninamide

Guidance literature:: Multi-step reaction with 4 steps

1: 50 percent / MnO₂ / ethyl acetate / 0.75 h

2: 75 percent / 48percent aq. HBr; H₂SO₄ / 4 h

3: 65 percent / trimethyl orthoformate; p-TsOH / diethyl ether / 12 h / Heating

4: 80 percent / aq. NaHCO₃ / acetonitrile / 48 h / Heating

With manganese(IV) oxide; sulfuric acid; sodium hydrogencarbonate; toluene-4-sulfonic acid; trimethyl orthoformate; In diethyl ether; ethyl acetate; acetonitrile;
DOI:10.1021/jm0208572

Reference yield:

: 605-70-9
naphthalene-1,4-dicarboxylic acid

: 490038-29-4
N-{[4-(5,5-dimethyl-1,3-dioxan-2-yl)-1-naphthyl]methyl}-(S)-phenylalaninamide

Guidance literature:: Multi-step reaction with 5 steps

1: 70 percent / LiAlH₄ / tetrahydrofuran / 48 h / Heating

2: 50 percent / MnO₂ / ethyl acetate / 0.75 h

3: 75 percent / 48percent aq. HBr; H₂SO₄ / 4 h

4: 65 percent / trimethyl orthoformate; p-TsOH / diethyl ether / 12 h / Heating

5: 80 percent / aq. NaHCO₃ / acetonitrile / 48 h / Heating

With manganese(IV) oxide; lithium aluminium tetrahydride; sulfuric acid; sodium hydrogencarbonate; toluene-4-sulfonic acid; trimethyl orthoformate; In tetrahydrofuran; diethyl ether; ethyl acetate; acetonitrile;
DOI:10.1021/jm0208572