(2S,4R)-2-tert-butoxycarbonylamino-4-[(tert-butyldiphenylsilyloxy)methyl]-4-butanolide

Base Information

Chemical Name:(2S,4R)-2-tert-butoxycarbonylamino-4-[(tert-butyldiphenylsilyloxy)methyl]-4-butanolide
CAS No.:911225-56-4
Molecular Formula:C₂₆H₃₅NO₅Si
Molecular Weight:469.653
Hs Code.:

Synonyms:(2S,4R)-2-tert-butoxycarbonylamino-4-[(tert-butyldiphenylsilyloxy)methyl]-4-butanolide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,4R)-2-tert-butoxycarbonylamino-4-[(tert-butyldiphenylsilyloxy)methyl]-4-butanolide

Chemical Property:

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Technology Process of (2S,4R)-2-tert-butoxycarbonylamino-4-[(tert-butyldiphenylsilyloxy)methyl]-4-butanolide

There total 8 articles about (2S,4R)-2-tert-butoxycarbonylamino-4-[(tert-butyldiphenylsilyloxy)methyl]-4-butanolide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 911225-55-3
(2S,4R)-2-amino-4-[(tert-butyldiphenylsilyloxy)methyl]-4-butanolide

: 24424-99-5
di-tert-butyl dicarbonate

: 911225-56-4
(2S,4R)-2-tert-butoxycarbonylamino-4-[(tert-butyldiphenylsilyloxy)methyl]-4-butanolide

Guidance literature:: With triethylamine; In 1,4-dioxane; at 20 ℃; for 12h;
DOI:10.1016/j.tet.2006.06.105

Reference yield:

: 911225-54-2
(2S,4R)-2-azido-4-[(tert-butyldiphenylsilyloxy)methyl]-4-butanolide

: 911225-56-4
(2S,4R)-2-tert-butoxycarbonylamino-4-[(tert-butyldiphenylsilyloxy)methyl]-4-butanolide

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / triphenylphosphine / tetrahydrofuran / 0.5 h / 20 °C

2: 90 percent / triethylamine / dioxane / 12 h / 20 °C

With triethylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1016/j.tet.2006.06.105

Reference yield:

: 2-tert-butoxycarbonylamino-5-(tert-butyl-diphenyl-silanyloxy)-4-hydroxy-pentanoic acid

: 911225-56-4
(2S,4R)-2-tert-butoxycarbonylamino-4-[(tert-butyldiphenylsilyloxy)methyl]-4-butanolide

Guidance literature:: Multi-step reaction with 2 steps

1: 0.13 g / diethyl ether

2: N-methyl-N-(tert-butyldimethylsilyl) trifluoroacetamide

With N-methyl-N-tert-butyldimethylsilyl-1,1,1-trifluoroacetamide; In diethyl ether;
DOI:10.1016/j.tet.2006.06.105