N^α-ε<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysyl>-N^ε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysine p-toluenesulfonate salt

Base Information

• Chemical Name: N^α-ε<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysyl>-N^ε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysine p-toluenesulfonate salt
• CAS No.: 122903-77-9
• Molecular Formula: C₇H₈O₃S*C₂₄H₅₀N₄O₇Si₂
• Molecular Weight: 735.059

Synonyms:N^α-ε<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysyl>-N^ε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysine p-toluenesulfonate salt

Chemical Property of N^α-ε<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysyl>-N^ε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysine p-toluenesulfonate salt

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of N^α-ε<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysyl>-N^ε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysine p-toluenesulfonate salt

There total 4 articles about N^α-ε<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysyl>-N^ε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysine p-toluenesulfonate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

Nα-α-(tert-butyloxycarbonyl)-Nε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysyl>-Nε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysine (122903-59-7) + toluene-4-sulfonic acid (104-15-4) → Nα-ε<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysyl>-Nε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysine p-toluenesulfonate salt (122903-77-9)

Guidance literature:

at 27 - 30 ℃; for 0.75h;

DOI:10.1021/jo00284a031

Reference yield:

Nα-(tert-butyloxycarbonyl)-Nε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysine (85167-76-6) → Nα-ε<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysyl>-Nε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysine p-toluenesulfonate salt (122903-77-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent / N,N'-dicyclohexylcarbodiimide (DCC) / ethyl acetate / 24 h / Ambient temperature

2: 88 percent / N-ethyl-N,N-diisopropylamine (EDPA) / CH₂Cl₂ / 72 h / 25 - 30 °C

3: 94 percent / 0.75 h / 27 - 30 °C

With N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In dichloromethane; ethyl acetate;

DOI:10.1021/jo00284a031

Reference yield:

Nα-(tert-butyloxycarbonyl)-Nε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysine N-hydroxysuccinimide ester (122924-32-7) → Nα-ε<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysyl>-Nε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysine p-toluenesulfonate salt (122903-77-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / N-ethyl-N,N-diisopropylamine (EDPA) / CH₂Cl₂ / 72 h / 25 - 30 °C

2: 94 percent / 0.75 h / 27 - 30 °C

With N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1021/jo00284a031

upstream raw materials:

N^α-α-(tert-butyloxycarbonyl)-N^ε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysyl>-N^ε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysine

toluene-4-sulfonic acid

N^α-(tert-butyloxycarbonyl)-N^ε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysine N-hydroxysuccinimide ester

(S)-2-tert-Butoxycarbonylamino-6-(2-trimethylsilanyl-ethoxycarbonylamino)-hexanoic acid 3-nitro-phenyl ester

Downstream raw materials:

N^α-α-α-α-(9-fluorenylmethyloxycarbonyl)-N^ε-(benzyloxycarbonyl)-L-lysyl>-N^ε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysyl>-N^ε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysyl>-N^ε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysine

N^α-α-α-(tert-butyloxycarbonyl)-N^ε-(benzyloxycarbonyl)-L-lysyl>-N^ε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysyl>-N^ε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysine

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