2-Phenylpyridin-4-amine

Base Information

• Chemical Name: 2-Phenylpyridin-4-amine
• CAS No.: 21203-86-1
• Molecular Formula: C11H10 N2
• Molecular Weight: 170.214
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID00376494
• Nikkaji Number: J2.169.510F
• Wikidata: Q82165409
• Pharos Ligand ID: MADPJX2WVK6D
• ChEMBL ID: CHEMBL1770738
• Mol file: 21203-86-1.mol

Synonyms:2-phenylpyridin-4-amine;21203-86-1;4-Amino-2-phenylpyridine;2-PHENYL-PYRIDIN-4-YLAMINE;CHEMBL1770738;MFCD01646280;4-Pyridinamine,2-phenyl-;2-Phenyl-4-aminopyridine;2-phenylpyridin-4-ylamine;SCHEMBL3788626;DTXSID00376494;CHVKPWIABFICLK-UHFFFAOYSA-N;CS-D1566;BDBM50342659;AKOS006283666;AB09616;FS-3258;2-phenyl-pyridin-4-ylamine, AldrichCPR;SY032946;BB 0260403;FT-0649864;EN300-74480;A21788;J-514340;F2167-2399;Z1083217772

Chemical Property of 2-Phenylpyridin-4-amine

Chemical Property:

• Vapor Pressure: 4.16E-06mmHg at 25°C
• Refractive Index: 1.625
• Boiling Point: 384.2°Cat760mmHg
• Flash Point: 214.4°C
• PSA: 38.91000
• Density: 1.133g/cm³
• LogP: 2.91200
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 170.084398327
• Heavy Atom Count: 13
• Complexity: 152

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Amino-2-phenylpyridine ^*data from reagent suppliers

Safty Information:

• Statements: 41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=NC=CC(=C2)N

Technology Process of 2-Phenylpyridin-4-amine

There total 7 articles about 2-Phenylpyridin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-bromo-4-aminopyridine (7598-35-8) + phenylboronic acid (98-80-6) → 2-phenyl-pyridin-4-ylamine (21203-86-1)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; carbon dioxide; In water; acetonitrile; at 70 ℃; for 24h; under 23257.6 Torr; Reagent/catalyst; Pressure; Inert atmosphere;

DOI:10.1039/c4ob01630k

Reference yield: 98.0%

4-Amino-2-chloropyridine (14432-12-3) + phenylboronic acid (98-80-6) → 2-phenyl-pyridin-4-ylamine (21203-86-1)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; carbon dioxide; In water; acetonitrile; at 70 ℃; for 24h; under 5168.35 Torr; Pressure; Reagent/catalyst; Autoclave;

DOI:10.1039/c4ob01630k

Reference yield: 75.0%

2-Amino-4-chloropyridine (19798-80-2) + phenylboronic acid (98-80-6) → 2-phenyl-pyridin-4-ylamine (21203-86-1)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; water; toluene; at 90 ℃; for 14h; Sealed tube; Inert atmosphere;

upstream raw materials:

4-Amino-2-chloropyridine

phenylboronic acid

2-bromo-4-aminopyridine

chlorobenzene

Downstream raw materials:

5-iodo-2-phenyl-pyridin-4-ylamine

4-phenoxy-2-phenylpyridine

4-chloro-2-phenyl-pyridine

Refernces

• 1、 -. "N-pyridine-4-yl-benzamide Cdc37 inhibitor as well as derivative and application thereof". Paragraph 0117-0120. . Retrieved 2021/05/19.
• 2、 -. "NEW BENZAMIDE DERIVATIVES AS PPAR-GAMMA MODULATORS". Paragraph 0097-0098. . Retrieved 2019/06/27.