(4R,5S,4'S,5'R,1S,2S)-4,5-dihydro-2-(1-tertbutyloxycarbonylamino-2-methyl-1-butyl)-4-[(1',5'-dimethyl-4'-phenylimidazolidin-2'-on-3'-yl)carbonyl]-5-methyloxazole

Base Information

Chemical Name:(4R,5S,4'S,5'R,1S,2S)-4,5-dihydro-2-(1-tertbutyloxycarbonylamino-2-methyl-1-butyl)-4-[(1',5'-dimethyl-4'-phenylimidazolidin-2'-on-3'-yl)carbonyl]-5-methyloxazole
CAS No.:272113-86-7
Molecular Formula:C₂₆H₃₈N₄O₅
Molecular Weight:486.612
Hs Code.:

(4R,5S,4'S,5'R,1S,2S)-4,5-dihydro-2-(1-tertbutyloxycarbonylamino-2-methyl-1-butyl)-4-[(1',5'-dimethyl-4'-phenylimidazolidin-2'-on-3'-yl)carbonyl]-5-methyloxazole

Synonyms:(4R,5S,4'S,5'R,1S,2S)-4,5-dihydro-2-(1-tertbutyloxycarbonylamino-2-methyl-1-butyl)-4-[(1',5'-dimethyl-4'-phenylimidazolidin-2'-on-3'-yl)carbonyl]-5-methyloxazole

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Chemical Property of (4R,5S,4'S,5'R,1S,2S)-4,5-dihydro-2-(1-tertbutyloxycarbonylamino-2-methyl-1-butyl)-4-[(1',5'-dimethyl-4'-phenylimidazolidin-2'-on-3'-yl)carbonyl]-5-methyloxazole

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Technology Process of (4R,5S,4'S,5'R,1S,2S)-4,5-dihydro-2-(1-tertbutyloxycarbonylamino-2-methyl-1-butyl)-4-[(1',5'-dimethyl-4'-phenylimidazolidin-2'-on-3'-yl)carbonyl]-5-methyloxazole

There total 3 articles about (4R,5S,4'S,5'R,1S,2S)-4,5-dihydro-2-(1-tertbutyloxycarbonylamino-2-methyl-1-butyl)-4-[(1',5'-dimethyl-4'-phenylimidazolidin-2'-on-3'-yl)carbonyl]-5-methyloxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 272113-85-6
(4R,5S,2'S,3'R)-1,5-dimethyl-3-[(1'-BOCisoleucyl-3'-methyl-2'-azyridinyl)carbonyl]-4-phenylimidazolidin-2-one

: 272113-86-7
(4R,5S,4'S,5'R,1S,2S)-4,5-dihydro-2-(1-tertbutyloxycarbonylamino-2-methyl-1-butyl)-4-[(1',5'-dimethyl-4'-phenylimidazolidin-2'-on-3'-yl)carbonyl]-5-methyloxazole

Guidance literature:: With boron trifluoride diethyl etherate; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/ol005659o

Reference yield:

: 13139-16-7
N-(tert-butyloxycarbonyl)-L-isoleucine

: 272113-86-7
(4R,5S,4'S,5'R,1S,2S)-4,5-dihydro-2-(1-tertbutyloxycarbonylamino-2-methyl-1-butyl)-4-[(1',5'-dimethyl-4'-phenylimidazolidin-2'-on-3'-yl)carbonyl]-5-methyloxazole

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / dicyclohexylcarbodiimide / CH₂Cl₂ / 12 h / 20 °C

2: 90 percent / BF₃*Et₂O / CH₂Cl₂ / 2 h / 20 °C

With boron trifluoride diethyl etherate; dicyclohexyl-carbodiimide; In dichloromethane; 1: Acylation / 2: Rearrangement;
DOI:10.1021/ol005659o

Reference yield:

: 183074-26-2
(4R,5S)-1,5-Dimethyl-3-((2S,3R)-3-methyl-aziridine-2-carbonyl)-4-phenyl-imidazolidin-2-one

: 272113-86-7
(4R,5S,4'S,5'R,1S,2S)-4,5-dihydro-2-(1-tertbutyloxycarbonylamino-2-methyl-1-butyl)-4-[(1',5'-dimethyl-4'-phenylimidazolidin-2'-on-3'-yl)carbonyl]-5-methyloxazole

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / dicyclohexylcarbodiimide / CH₂Cl₂ / 12 h / 20 °C

2: 90 percent / BF₃*Et₂O / CH₂Cl₂ / 2 h / 20 °C

With boron trifluoride diethyl etherate; dicyclohexyl-carbodiimide; In dichloromethane; 1: Acylation / 2: Rearrangement;
DOI:10.1021/ol005659o