2,3-Dihydro-1H-cyclopenta[A]naphthalene-2-carboxylic acid

Base Information

• Chemical Name: 2,3-Dihydro-1H-cyclopenta[A]naphthalene-2-carboxylic acid
• CAS No.: 209224-98-6
• Molecular Formula: C₁₄H₁₂O₂
• Molecular Weight: 212.248
• DSSTox Substance ID: DTXSID50456194
• Mol file: 209224-98-6.mol

Synonyms:209224-98-6;2,3-DIHYDRO-1H-CYCLOPENTA[A]NAPHTHALENE-2-CARBOXYLIC ACID;SCHEMBL6990855;DTXSID50456194;2,3-DIHYDRO-1H-CYCLOPENTA[A]NAPHTHALENE-2-CARBOXYLICACID

Chemical Property of 2,3-Dihydro-1H-cyclopenta[A]naphthalene-2-carboxylic acid

Chemical Property:

• Boiling Point: 430.0±34.0 °C(Predicted)
• PKA: 4.41±0.20(Predicted)
• PSA: 37.30000
• Density: 1.287±0.06 g/cm3(Predicted)
• LogP: 2.63920
• XLogP3: 3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 212.083729621
• Heavy Atom Count: 16
• Complexity: 287

Purity/Quality:

97% ^*data from raw suppliers

2,3-DIHYDRO-1H-CYCLOPENTA[A]NAPHTHALENE-2-CARBOXYLIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C(CC2=C1C=CC3=CC=CC=C23)C(=O)O

Technology Process of 2,3-Dihydro-1H-cyclopenta[A]naphthalene-2-carboxylic acid

There total 4 articles about 2,3-Dihydro-1H-cyclopenta[A]naphthalene-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,3-dihydro-cyclopenta[a]naphthalene-2,2-dicarboxylic acid → (+/-)-2,3-dihydro-1H-cyclopenta[α]naphthalene-2-carboxylic acid (209224-98-6,209225-02-5,209225-03-6)

Guidance literature:

In dichloromethane; at 200 ℃; for 0.166667h;

DOI:10.1021/jm025513q

Reference yield:

1,2-bis(bromomethyl)naphthalene (59882-98-3) → (+/-)-2,3-dihydro-1H-cyclopenta[α]naphthalene-2-carboxylic acid (209224-98-6,209225-02-5,209225-03-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C

1.2: tetrahydrofuran / 15 h / 20 °C

2.1: aq. KOH / ethanol / 3 h / 80 °C

3.1: 15.59 g / CH₂Cl₂ / 0.17 h / 200 °C

With potassium hydroxide; sodium hydride; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1021/jm025513q

Reference yield:

1,3-dihydro-cyclopenta[a]naphthalene-2,2-dicarboxylic acid diethyl ester → (+/-)-2,3-dihydro-1H-cyclopenta[α]naphthalene-2-carboxylic acid (209224-98-6,209225-02-5,209225-03-6)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. KOH / ethanol / 3 h / 80 °C

2: 15.59 g / CH₂Cl₂ / 0.17 h / 200 °C

With potassium hydroxide; In ethanol; dichloromethane;

DOI:10.1021/jm025513q

upstream raw materials:

1,2-bis(bromomethyl)naphthalene