tert-butyl (2-{4-[4-({[(4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)carbonyl]amino}methyl)benzyl]piperazin-1-yl}ethyl)carbamate

Base Information

Chemical Name:tert-butyl (2-{4-[4-({[(4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)carbonyl]amino}methyl)benzyl]piperazin-1-yl}ethyl)carbamate
CAS No.:1456890-56-4
Molecular Formula:C₂₆H₃₄N₆O₄S
Molecular Weight:526.66
Hs Code.:

Synonyms:tert-butyl (2-{4-[4-({[(4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)carbonyl]amino}methyl)benzyl]piperazin-1-yl}ethyl)carbamate

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Chemical Property of tert-butyl (2-{4-[4-({[(4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)carbonyl]amino}methyl)benzyl]piperazin-1-yl}ethyl)carbamate

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Technology Process of tert-butyl (2-{4-[4-({[(4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)carbonyl]amino}methyl)benzyl]piperazin-1-yl}ethyl)carbamate

There total 9 articles about tert-butyl (2-{4-[4-({[(4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)carbonyl]amino}methyl)benzyl]piperazin-1-yl}ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 4-oxo-N-[4-(piperazin-1-ylmethyl)benzyl]-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide dihydrochloride

: 89711-08-0
N-(t-butoxycarbonyl)glycinal

: 1456890-56-4
tert-butyl (2-{4-[4-({[(4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)carbonyl]amino}methyl)benzyl]piperazin-1-yl}ethyl)carbamate

Guidance literature:: 4-oxo-N-[4-(piperazin-1-ylmethyl)benzyl]-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide dihydrochloride; N-(t-butoxycarbonyl)glycinal; In N,N-dimethyl acetamide; at 55 ℃; for 14h; Inert atmosphere;

With sodium tris(acetoxy)borohydride; In N,N-dimethyl acetamide; at 55 ℃; for 24h; Inert atmosphere;
DOI:10.1021/jm400718n

Reference yield:

: 844502-63-2
3-ethyl 4-methyl 2-aminothiophene-3,4-dicarboxylate

: 1456890-56-4
tert-butyl (2-{4-[4-({[(4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)carbonyl]amino}methyl)benzyl]piperazin-1-yl}ethyl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: ethanol / 70 h / Inert atmosphere; Reflux

2.1: triethylamine / ethanol / 12 h / Inert atmosphere; Reflux

3.1: hydrogenchloride / 1,4-dioxane / 1 h / 0 - 20 °C / Inert atmosphere

4.1: titanium(IV) isopropylate / tetrahydrofuran / 12 h / 45 °C / Inert atmosphere

4.2: 24 h / 45 °C / Inert atmosphere

5.1: hydrogenchloride / 1,4-dioxane / 2 h / 0 - 20 °C / Inert atmosphere

6.1: N,N-dimethyl acetamide / 14 h / 55 °C / Inert atmosphere

6.2: 24 h / 55 °C / Inert atmosphere

With titanium(IV) isopropylate; hydrogenchloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl acetamide;
DOI:10.1021/jm400718n

Reference yield:

: 1456890-54-2
tert-Butyl 4-[4-({[(4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)carbonyl]amino}methyl) benzyl]piperazine-1-carboxylate

: 1456890-56-4
tert-butyl (2-{4-[4-({[(4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)carbonyl]amino}methyl)benzyl]piperazin-1-yl}ethyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / 1,4-dioxane / 2 h / 0 - 20 °C / Inert atmosphere

2.1: N,N-dimethyl acetamide / 14 h / 55 °C / Inert atmosphere

2.2: 24 h / 55 °C / Inert atmosphere

With hydrogenchloride; In 1,4-dioxane; N,N-dimethyl acetamide;
DOI:10.1021/jm400718n