tert-butyl ((S)-1-(((S)-1-cyclohexyl-2-((S)-2-(fluorocarbonyl)pyrrolidin-1-yl)-2-oxoethyl)amino)-1-oxopropan-2-yl)(methyl)carbamate

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Chemical Name:tert-butyl ((S)-1-(((S)-1-cyclohexyl-2-((S)-2-(fluorocarbonyl)pyrrolidin-1-yl)-2-oxoethyl)amino)-1-oxopropan-2-yl)(methyl)carbamate
CAS No.:873581-32-9
Molecular Formula:C₂₂H₃₆FN₃O₅
Molecular Weight:441.543
Hs Code.:

Synonyms:tert-butyl ((S)-1-(((S)-1-cyclohexyl-2-((S)-2-(fluorocarbonyl)pyrrolidin-1-yl)-2-oxoethyl)amino)-1-oxopropan-2-yl)(methyl)carbamate

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Chemical Property of tert-butyl ((S)-1-(((S)-1-cyclohexyl-2-((S)-2-(fluorocarbonyl)pyrrolidin-1-yl)-2-oxoethyl)amino)-1-oxopropan-2-yl)(methyl)carbamate

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Technology Process of tert-butyl ((S)-1-(((S)-1-cyclohexyl-2-((S)-2-(fluorocarbonyl)pyrrolidin-1-yl)-2-oxoethyl)amino)-1-oxopropan-2-yl)(methyl)carbamate

There total 5 articles about tert-butyl ((S)-1-(((S)-1-cyclohexyl-2-((S)-2-(fluorocarbonyl)pyrrolidin-1-yl)-2-oxoethyl)amino)-1-oxopropan-2-yl)(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 873581-17-0
(2S)-1-[(2S)-2-[(2S)-2-[[(tert-butoxy)carbonyl](methyl)amino]propanamido]-2-cyclohexylacetyl]pyrrolidine-2-carboxylic acid

: 873581-32-9
tert-butyl ((S)-1-(((S)-1-cyclohexyl-2-((S)-2-(fluorocarbonyl)pyrrolidin-1-yl)-2-oxoethyl)amino)-1-oxopropan-2-yl)(methyl)carbamate

Guidance literature:: With pyridine; trifluoro-[1,3,5]triazine; In dichloromethane; at 0 - 20 ℃; for 5.25833h;

Reference yield:

: 894789-27-6
(2S)-2-[(2S)-2-[[(tert-butoxy)carbonyl](methyl)amino]propanamido]-2-cyclohexylacetic acid

: 873581-32-9
tert-butyl ((S)-1-(((S)-1-cyclohexyl-2-((S)-2-(fluorocarbonyl)pyrrolidin-1-yl)-2-oxoethyl)amino)-1-oxopropan-2-yl)(methyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; 4-methyl-morpholine / tetrahydrofuran; N,N-dimethyl-formamide / 20 °C

2: water; lithium hydroxide monohydrate / acetone / 1 h / 0 °C

3: trifluoro-[1,3,5]triazine; pyridine / dichloromethane / 1 h / 0 °C

With 4-methyl-morpholine; pyridine; trifluoro-[1,3,5]triazine; lithium hydroxide monohydrate; water; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1514923-26-2
methyl ((S)-2-((S)-2-((tert-butoxycarbonyl)(methyl)amino)propanamido)-2-cyclohexylacetyl)-L-prolinate

: 873581-32-9
tert-butyl ((S)-1-(((S)-1-cyclohexyl-2-((S)-2-(fluorocarbonyl)pyrrolidin-1-yl)-2-oxoethyl)amino)-1-oxopropan-2-yl)(methyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: water; lithium hydroxide monohydrate / acetone / 1 h / 0 °C

2: trifluoro-[1,3,5]triazine; pyridine / dichloromethane / 1 h / 0 °C

With pyridine; trifluoro-[1,3,5]triazine; lithium hydroxide monohydrate; water; In dichloromethane; acetone;