2-butyl-1-<2'-<(1,1-dimethylethoxy)carbonyl><1,1'-biphenyl>-4-yl>-6-chloro-1,4-dihydro-4,4-dimethyl-5-pyrimidinecarboxylic acid, ethyl ester

Base Information

Chemical Name:2-butyl-1-<2'-<(1,1-dimethylethoxy)carbonyl><1,1'-biphenyl>-4-yl>-6-chloro-1,4-dihydro-4,4-dimethyl-5-pyrimidinecarboxylic acid, ethyl ester
CAS No.:142385-39-5
Molecular Formula:C₃₁H₃₉ClN₂O₄
Molecular Weight:539.115
Hs Code.:

Synonyms:2-butyl-1-<2'-<(1,1-dimethylethoxy)carbonyl><1,1'-biphenyl>-4-yl>-6-chloro-1,4-dihydro-4,4-dimethyl-5-pyrimidinecarboxylic acid, ethyl ester

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Chemical Property of 2-butyl-1-<2'-<(1,1-dimethylethoxy)carbonyl><1,1'-biphenyl>-4-yl>-6-chloro-1,4-dihydro-4,4-dimethyl-5-pyrimidinecarboxylic acid, ethyl ester

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Technology Process of 2-butyl-1-<2'-<(1,1-dimethylethoxy)carbonyl><1,1'-biphenyl>-4-yl>-6-chloro-1,4-dihydro-4,4-dimethyl-5-pyrimidinecarboxylic acid, ethyl ester

There total 3 articles about 2-butyl-1-<2'-<(1,1-dimethylethoxy)carbonyl><1,1'-biphenyl>-4-yl>-6-chloro-1,4-dihydro-4,4-dimethyl-5-pyrimidinecarboxylic acid, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.1%

: 114772-40-6
4'-bromomethyl-biphenyl-2-carboxylic acid tert-butyl ester

: 142385-38-4
6-butyl-4-chloro-1,2-dihydro-2,2-dimethyl-5-pyrimidinecarboxylic acid, ethyl ester

: 142385-39-5
2-butyl-1-<2'-<(1,1-dimethylethoxy)carbonyl><1,1'-biphenyl>-4-yl>-6-chloro-1,4-dihydro-4,4-dimethyl-5-pyrimidinecarboxylic acid, ethyl ester

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; for 5h; Ambient temperature;
DOI:10.1021/jm00103a014

Reference yield:

: 6802-75-1
diethyl isopropylidenemalonate

: 142385-39-5
2-butyl-1-<2'-<(1,1-dimethylethoxy)carbonyl><1,1'-biphenyl>-4-yl>-6-chloro-1,4-dihydro-4,4-dimethyl-5-pyrimidinecarboxylic acid, ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) potassium tert-butoxide / 1.) DMF, 0 deg C, 30 min, 2.) DMF, RT, 16 h

2: 31.8 percent / phosphorus oxychloride / 12 h / 120 °C

3: 91.1 percent / cesium carbonate / dimethylformamide / 5 h / Ambient temperature

With potassium tert-butylate; caesium carbonate; trichlorophosphate; In N,N-dimethyl-formamide;
DOI:10.1021/jm00103a014

Reference yield:

: 142385-37-3
2-butyl-6,6-dimethyl-4-oxo-1,4,5,6-tetrahydropyrimidine-5-carboxylic acid, ethyl ester

: 142385-39-5
2-butyl-1-<2'-<(1,1-dimethylethoxy)carbonyl><1,1'-biphenyl>-4-yl>-6-chloro-1,4-dihydro-4,4-dimethyl-5-pyrimidinecarboxylic acid, ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 31.8 percent / phosphorus oxychloride / 12 h / 120 °C

2: 91.1 percent / cesium carbonate / dimethylformamide / 5 h / Ambient temperature

With caesium carbonate; trichlorophosphate; In N,N-dimethyl-formamide;
DOI:10.1021/jm00103a014