N-(4-(2-amino-3-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yloxy)-2,5-difluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Base Information

Chemical Name:N-(4-(2-amino-3-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yloxy)-2,5-difluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
CAS No.:1345855-16-4
Molecular Formula:C₂₉H₂₃F₃N₆O₄
Molecular Weight:576.535
Hs Code.:

Synonyms:N-(4-(2-amino-3-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yloxy)-2,5-difluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-(2-amino-3-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yloxy)-2,5-difluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-(4-(2-amino-3-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yloxy)-2,5-difluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

There total 17 articles about N-(4-(2-amino-3-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yloxy)-2,5-difluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1345855-15-3
N-(4-(2-[bis[(1,1-dimethylethoxy)carbonyl]amino]-3-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yloxy)-2,5-difluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

: 1345855-16-4
N-(4-(2-amino-3-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yloxy)-2,5-difluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Guidance literature:: N-(4-(2-[bis[(1,1-dimethylethoxy)carbonyl]amino]-3-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yloxy)-2,5-difluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

: 105-56-6
ethyl 2-cyanoacetate

: 1345855-16-4
N-(4-(2-amino-3-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yloxy)-2,5-difluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: acetic acid / 120 - 130 °C

2.1: 2 h / 70 °C

3.1: acetic acid / Reflux

3.2: pH ~ 9 - 10

4.1: pyridine / copper diacetate / dichloromethane / 4 h / 25 °C

5.1: water; lithium hydroxide / ethanol / 16 h / 25 °C

5.2: pH < 2

6.1: thionyl chloride / 1 h / 60 °C

7.1: triethylamine / tetrahydrofuran / 2 h / 20 °C

8.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With pyridine; thionyl chloride; water; acetic acid; triethylamine; trifluoroacetic acid; lithium hydroxide; copper diacetate; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

: 35260-93-6,932750-29-3
ethyl 2-cyano-3-ethoxybut-2-enoate

: 1345855-16-4
N-(4-(2-amino-3-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yloxy)-2,5-difluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: 2 h / 70 °C

2.1: acetic acid / Reflux

2.2: pH ~ 9 - 10

3.1: pyridine / copper diacetate / dichloromethane / 4 h / 25 °C

4.1: water; lithium hydroxide / ethanol / 16 h / 25 °C

4.2: pH < 2

5.1: thionyl chloride / 1 h / 60 °C

6.1: triethylamine / tetrahydrofuran / 2 h / 20 °C

7.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With pyridine; thionyl chloride; water; acetic acid; triethylamine; trifluoroacetic acid; lithium hydroxide; copper diacetate; In tetrahydrofuran; ethanol; dichloromethane;