(2S,7R)-N-benzyloxycarbonyl-2-[2-N-benzyloxycarbonyl-(4,4-diethoxybutyl)amino]-hept-4-enyl-2,5-dihydropyrrole

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Chemical Name:(2S,7R)-N-benzyloxycarbonyl-2-[2-N-benzyloxycarbonyl-(4,4-diethoxybutyl)amino]-hept-4-enyl-2,5-dihydropyrrole
CAS No.:309248-78-0
Molecular Formula:C₃₅H₄₈N₂O₆
Molecular Weight:592.776
Hs Code.:

Synonyms:(2S,7R)-N-benzyloxycarbonyl-2-[2-N-benzyloxycarbonyl-(4,4-diethoxybutyl)amino]-hept-4-enyl-2,5-dihydropyrrole

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Chemical Property of (2S,7R)-N-benzyloxycarbonyl-2-[2-N-benzyloxycarbonyl-(4,4-diethoxybutyl)amino]-hept-4-enyl-2,5-dihydropyrrole

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Technology Process of (2S,7R)-N-benzyloxycarbonyl-2-[2-N-benzyloxycarbonyl-(4,4-diethoxybutyl)amino]-hept-4-enyl-2,5-dihydropyrrole

There total 5 articles about (2S,7R)-N-benzyloxycarbonyl-2-[2-N-benzyloxycarbonyl-(4,4-diethoxybutyl)amino]-hept-4-enyl-2,5-dihydropyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 10250-52-9
1,1-diiodopropane

: 309248-76-8
(3R,4S)-3-[N-benzyloxycarbonyl-(4,4-diethoxybutyl)amino]-4-(N-benzyloxycarbonyl-2,5-dihydropyrrol-2-yl)butyraldehyde

: 309248-78-0
(2S,7R)-N-benzyloxycarbonyl-2-[2-N-benzyloxycarbonyl-(4,4-diethoxybutyl)amino]-hept-4-enyl-2,5-dihydropyrrole

Guidance literature:: With chromium dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; for 1h;
DOI:10.1021/ja001688i

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 309248-78-0
(2S,7R)-N-benzyloxycarbonyl-2-[2-N-benzyloxycarbonyl-(4,4-diethoxybutyl)amino]-hept-4-enyl-2,5-dihydropyrrole

Guidance literature:: Multi-step reaction with 3 steps

1: 620 mg / dimethylformamide / 0.17 h / 20 °C

2: 72 percent / oxygen; PdCl₂; CuCl / dimethylformamide; H₂O / 6 h

3: 70 percent / CrCl₂; DMF / tetrahydrofuran / 1 h

With chromium dichloride; oxygen; N,N-dimethyl-formamide; copper(l) chloride; palladium dichloride; In tetrahydrofuran; water; N,N-dimethyl-formamide; 3: Takai olefination;
DOI:10.1021/ja001688i

Reference yield:

: (4,4-Diethoxy-butyl)-{(R)-1-[(S)-1-(2,5-dihydro-1H-pyrrol-2-yl)methyl]-allyl}-amine

: 309248-78-0
(2S,7R)-N-benzyloxycarbonyl-2-[2-N-benzyloxycarbonyl-(4,4-diethoxybutyl)amino]-hept-4-enyl-2,5-dihydropyrrole

Guidance literature:: Multi-step reaction with 3 steps

1: 620 mg / dimethylformamide / 0.17 h / 20 °C

2: 72 percent / oxygen; PdCl₂; CuCl / dimethylformamide; H₂O / 6 h

3: 70 percent / CrCl₂; DMF / tetrahydrofuran / 1 h

With chromium dichloride; oxygen; N,N-dimethyl-formamide; copper(l) chloride; palladium dichloride; In tetrahydrofuran; water; N,N-dimethyl-formamide; 3: Takai olefination;
DOI:10.1021/ja001688i