(5R)-1-Aza-3(R)-phenyl-4(S)-(benzoylmethyl)-4(S)-carboxy-6(R)-hydroxybicyclo<3.3.0>octane Lactone

Base Information

Chemical Name:(5R)-1-Aza-3(R)-phenyl-4(S)-(benzoylmethyl)-4(S)-carboxy-6(R)-hydroxybicyclo<3.3.0>octane Lactone
CAS No.:126191-55-7
Molecular Formula:C₂₂H₂₁NO₄
Molecular Weight:363.413
Hs Code.:

Synonyms:(5R)-1-Aza-3(R)-phenyl-4(S)-(benzoylmethyl)-4(S)-carboxy-6(R)-hydroxybicyclo<3.3.0>octane Lactone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (5R)-1-Aza-3(R)-phenyl-4(S)-(benzoylmethyl)-4(S)-carboxy-6(R)-hydroxybicyclo<3.3.0>octane Lactone

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Technology Process of (5R)-1-Aza-3(R)-phenyl-4(S)-(benzoylmethyl)-4(S)-carboxy-6(R)-hydroxybicyclo<3.3.0>octane Lactone

There total 2 articles about (5R)-1-Aza-3(R)-phenyl-4(S)-(benzoylmethyl)-4(S)-carboxy-6(R)-hydroxybicyclo<3.3.0>octane Lactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 126191-53-5
7-O-(Phenoxythiocarbonyl)-9-O-benzoylretronecine

: 126191-55-7
(5R)-1-Aza-3(R)-phenyl-4(S)-(benzoylmethyl)-4(S)-carboxy-6(R)-hydroxybicyclo<3.3.0>octane Lactone

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; at 75 ℃; for 3h;
DOI:10.1021/jo00297a081

Reference yield:

: 95363-37-4
9-O-Benzoylretronecine

: 126191-55-7
(5R)-1-Aza-3(R)-phenyl-4(S)-(benzoylmethyl)-4(S)-carboxy-6(R)-hydroxybicyclo<3.3.0>octane Lactone

Guidance literature:: Multi-step reaction with 2 steps

1: 58 percent / 4-(dimethylamino)pyridine / acetonitrile / 48 h / Ambient temperature

2: 60 percent / 2,2'-azobis(2-methylpropionitrile), n-Bu₃SnH / toluene / 3 h / 75 °C

With dmap; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; acetonitrile;
DOI:10.1021/jo00297a081