N-((4-chlorophenyl)ethynyl)-N-methylmethanesulfonamide

Base Information

• Chemical Name: N-((4-chlorophenyl)ethynyl)-N-methylmethanesulfonamide
• CAS No.: 1333483-16-1
• Molecular Formula: C₁₀H₁₀ClNO₂S
• Molecular Weight: 243.714
• Mol file: 1333483-16-1.mol

Synonyms:N-((4-chlorophenyl)ethynyl)-N-methylmethanesulfonamide

Chemical Property of N-((4-chlorophenyl)ethynyl)-N-methylmethanesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-((4-chlorophenyl)ethynyl)-N-methylmethanesulfonamide

There total 3 articles about N-((4-chlorophenyl)ethynyl)-N-methylmethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

N-methylmethane sulphonamide (1184-85-6) + 1-(bromoethynyl)-4-chlorobenzene (33491-03-1) → N-((4-chlorophenyl)ethynyl)-N-methylmethanesulfonamide (1333483-16-1)

Guidance literature:

With 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; potassium carbonate; In toluene; at 80 ℃; for 12h; Inert atmosphere;

DOI:10.1039/c6cc02776h

Reference yield:

4-n-chlorophenylacetylene (873-73-4) → N-((4-chlorophenyl)ethynyl)-N-methylmethanesulfonamide (1333483-16-1)

Guidance literature:

Multi-step reaction with 2 steps

1: N-Bromosuccinimide; silver nitrate / acetone / 2 h / 20 °C / Inert atmosphere

2: copper(ll) sulfate pentahydrate; 1,10-Phenanthroline; potassium carbonate; toluene / 80 °C / Inert atmosphere

With N-Bromosuccinimide; 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; potassium carbonate; silver nitrate; toluene; In acetone;

DOI:10.1021/ol503172h

Reference yield:

4-n-chlorophenylacetylene (873-73-4) + N-methylmethane sulphonamide (1184-85-6) → N-((4-chlorophenyl)ethynyl)-N-methylmethanesulfonamide (1333483-16-1)

Guidance literature:

4-n-chlorophenylacetylene; With N-Bromosuccinimide; silver nitrate; In acetone; at 28 ℃; for 2h; Inert atmosphere;

N-methylmethane sulphonamide; With 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; potassium carbonate; In toluene; at 80 ℃; for 8h; Inert atmosphere;

DOI:10.1002/chem.201500694

upstream raw materials:

4-n-chlorophenylacetylene

N-methylmethane sulphonamide

1-(bromoethynyl)-4-chlorobenzene

Downstream raw materials:

3-(4-chlorophenyl)-2H-chromen-2-one