(2S,3R)-3-Hydroxy-2-methyl-2-methylsulfanyl-5-phenyl-pentanoic acid ethyl ester

Base Information

Chemical Name:(2S,3R)-3-Hydroxy-2-methyl-2-methylsulfanyl-5-phenyl-pentanoic acid ethyl ester
CAS No.:374591-03-4
Molecular Formula:C₁₅H₂₂O₃S
Molecular Weight:282.404
Hs Code.:

Synonyms:(2S,3R)-3-Hydroxy-2-methyl-2-methylsulfanyl-5-phenyl-pentanoic acid ethyl ester

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Chemical Property of (2S,3R)-3-Hydroxy-2-methyl-2-methylsulfanyl-5-phenyl-pentanoic acid ethyl ester

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Technology Process of (2S,3R)-3-Hydroxy-2-methyl-2-methylsulfanyl-5-phenyl-pentanoic acid ethyl ester

There total 2 articles about (2S,3R)-3-Hydroxy-2-methyl-2-methylsulfanyl-5-phenyl-pentanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 104-53-0
3-phenyl-propionaldehyde

: 1051925-20-2
(E/Z)-1-ethoxy-1-(trimethylsiloxy)-2-methylthiopropene

: 374591-03-4
(2S,3R)-3-Hydroxy-2-methyl-2-methylsulfanyl-5-phenyl-pentanoic acid ethyl ester

: (2R,3S)-3-Hydroxy-2-methyl-2-methylsulfanyl-5-phenyl-pentanoic acid ethyl ester

: (2S,3S)-3-Hydroxy-2-methyl-2-methylsulfanyl-5-phenyl-pentanoic acid ethyl ester

Guidance literature:: With dibutyltin diacetate; Sn(OTf)2*chiral diamine; In dichloromethane; at -78 ℃; for 1h;
DOI:10.1016/S0040-4039(01)01238-2

Reference yield:

: 40800-76-8
2-methylsulfanyl-propionic acid ethyl ester

: 374591-03-4
(2S,3R)-3-Hydroxy-2-methyl-2-methylsulfanyl-5-phenyl-pentanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: LDA

2: di-n-butyltin diacetate / Sn(OTf)2*chiral diamine / CH₂Cl₂ / 1 h / -78 °C

With dibutyltin diacetate; lithium diisopropyl amide; Sn(OTf)2*chiral diamine; In dichloromethane;
DOI:10.1016/S0040-4039(01)01238-2

Reference yield:

: 2186-92-7
p-Anisaldehyde dimethyl acetal

: 374591-03-4
(2S,3R)-3-Hydroxy-2-methyl-2-methylsulfanyl-5-phenyl-pentanoic acid ethyl ester

: (2S,4R,5S)-2-(4-Methoxy-phenyl)-5-methyl-4-phenethyl-[1,3]dioxane

Guidance literature:: (2S,3R)-3-Hydroxy-2-methyl-2-methylsulfanyl-5-phenyl-pentanoic acid ethyl ester; With lithium borohydride; In dichloromethane; at 20 ℃;

p-Anisaldehyde dimethyl acetal; With camphor-10-sulfonic acid; In dichloromethane; at 20 ℃;

With Raney Ni (W₅); In ethanol; Heating;
DOI:10.1016/S0040-4039(01)01238-2