3-[2-(2-Bromo-4,5-dimethoxy-phenyl)-ethyl]-1-(3,4-dimethoxy-phenyl)-7,8-dimethoxy-4-oxo-3,4-dihydro-chromeno[3,4-b]pyrrole-2-carboxylic acid

Base Information

Chemical Name:3-[2-(2-Bromo-4,5-dimethoxy-phenyl)-ethyl]-1-(3,4-dimethoxy-phenyl)-7,8-dimethoxy-4-oxo-3,4-dihydro-chromeno[3,4-b]pyrrole-2-carboxylic acid
CAS No.:187220-82-2
Molecular Formula:C₃₂H₃₀BrNO₁₀
Molecular Weight:668.495
Hs Code.:

Synonyms:3-[2-(2-Bromo-4,5-dimethoxy-phenyl)-ethyl]-1-(3,4-dimethoxy-phenyl)-7,8-dimethoxy-4-oxo-3,4-dihydro-chromeno[3,4-b]pyrrole-2-carboxylic acid

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Chemical Property of 3-[2-(2-Bromo-4,5-dimethoxy-phenyl)-ethyl]-1-(3,4-dimethoxy-phenyl)-7,8-dimethoxy-4-oxo-3,4-dihydro-chromeno[3,4-b]pyrrole-2-carboxylic acid

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Technology Process of 3-[2-(2-Bromo-4,5-dimethoxy-phenyl)-ethyl]-1-(3,4-dimethoxy-phenyl)-7,8-dimethoxy-4-oxo-3,4-dihydro-chromeno[3,4-b]pyrrole-2-carboxylic acid

There total 2 articles about 3-[2-(2-Bromo-4,5-dimethoxy-phenyl)-ethyl]-1-(3,4-dimethoxy-phenyl)-7,8-dimethoxy-4-oxo-3,4-dihydro-chromeno[3,4-b]pyrrole-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2460-33-5
3,4-dimethoxyphenylpyruvic acid

: 187220-82-2
3-[2-(2-Bromo-4,5-dimethoxy-phenyl)-ethyl]-1-(3,4-dimethoxy-phenyl)-7,8-dimethoxy-4-oxo-3,4-dihydro-chromeno[3,4-b]pyrrole-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) n-BuLi, I₂, 2.) MS 4A / 1.) THF, hexane, -78 deg C, 20 min; r.t., 1 h, 2.) r.t., 12 h

2: 71 percent / Pb(OAc)4 / ethyl acetate / 1 h / Heating

With lead(IV) acetate; n-butyllithium; iodine; In ethyl acetate;
DOI:10.1002/anie.199701551

Reference yield:

: 2-(2-bromo-4,5-dimethoxyphenyl)ethan-1-amine hydrobromide

: 187220-82-2
3-[2-(2-Bromo-4,5-dimethoxy-phenyl)-ethyl]-1-(3,4-dimethoxy-phenyl)-7,8-dimethoxy-4-oxo-3,4-dihydro-chromeno[3,4-b]pyrrole-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) n-BuLi, I₂, 2.) MS 4A / 1.) THF, hexane, -78 deg C, 20 min; r.t., 1 h, 2.) r.t., 12 h

2: 71 percent / Pb(OAc)4 / ethyl acetate / 1 h / Heating

With lead(IV) acetate; n-butyllithium; iodine; In ethyl acetate;
DOI:10.1002/anie.199701551

Reference yield: 74.0%

: 187220-82-2
3-[2-(2-Bromo-4,5-dimethoxy-phenyl)-ethyl]-1-(3,4-dimethoxy-phenyl)-7,8-dimethoxy-4-oxo-3,4-dihydro-chromeno[3,4-b]pyrrole-2-carboxylic acid

: 181423-71-2
14-(3,4-dimethoxyphenyl)-2,3,11,12-tetramethoxy-8,9-dihydro-6H-chromeno[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one

Guidance literature:: With palladium diacetate; triethylamine; triphenylphosphine; In acetonitrile; at 150 ℃; for 5h;
DOI:10.1002/anie.199701551