Multi-step reaction with 7 steps
1.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 24 h / 20 °C
2.1: lithium hydroxide; water / tetrahydrofuran / 3 h / 20 °C
3.1: Eaton′s Reagent / 3 h / 150 °C
4.1: triethylamine / dichloromethane; N,N-dimethyl-formamide / 2 h
5.1: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; N,N-dimethyl-formamide / 1 h / 160 °C
6.1: trichlorophosphate / 0.33 h / 100 °C
7.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.17 h / 20 °C
7.2: 20 h / 20 °C
With
tetrakis(triphenylphosphine) palladium(0); Eaton′s Reagent; water; sodium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hydroxide; trichlorophosphate;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;