Technology Process of 2-cyclopropyl-1-[(4-fluorophenyl)sulfonyl]-1,2,2',3',5',6'-hexahydrospiro[indole-3,4'-thiopyran]-5-amine 1',1'-dioxide
There total 10 articles about 2-cyclopropyl-1-[(4-fluorophenyl)sulfonyl]-1,2,2',3',5',6'-hexahydrospiro[indole-3,4'-thiopyran]-5-amine 1',1'-dioxide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
palladium 10% on activated carbon; hydrogen;
In
ethyl acetate;
at 20 ℃;
for 4.5h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 0.25 h / -50 - -20 °C
1.2: -40 - 20 °C
2.1: trifluoroacetic acid / chloroform / 18 h / 0 - 50 °C
3.1: boron trifluoride diethyl etherate / tetrahydrofuran / 0.08 h / 0 °C
3.2: 3 h / 5 - 20 °C
4.1: triethylamine / 1,2-dichloro-ethane / 42 h / 80 °C
5.1: trifluoroacetic anhydride; urea hydrogen peroxide adduct / acetonitrile / 20 °C
6.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 2.5 h / 20 °C
7.1: acetic acid; nitric acid / 2 h / 20 °C
8.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 4.5 h / 20 °C
With
palladium 10% on activated carbon; boron trifluoride diethyl etherate; hydrogen; nitric acid; urea hydrogen peroxide adduct; acetic acid; triethylamine; trifluoroacetic acid; trifluoroacetic anhydride; lithium diisopropyl amide;
In
tetrahydrofuran; ethanol; n-heptane; chloroform; ethylbenzene; ethyl acetate; 1,2-dichloro-ethane; acetonitrile;
1.1: |Wittig Olefination / 1.2: |Wittig Olefination / 2.1: |Fischer Indole Synthesis;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: triethylamine / 1,2-dichloro-ethane / 42 h / 80 °C
2: trifluoroacetic anhydride; urea hydrogen peroxide adduct / acetonitrile / 20 °C
3: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 2.5 h / 20 °C
4: acetic acid; nitric acid / 2 h / 20 °C
5: palladium 10% on activated carbon; hydrogen / ethyl acetate / 4.5 h / 20 °C
With
palladium 10% on activated carbon; hydrogen; nitric acid; urea hydrogen peroxide adduct; acetic acid; triethylamine; trifluoroacetic anhydride;
In
tetrahydrofuran; ethanol; ethyl acetate; 1,2-dichloro-ethane; acetonitrile;
![2-cyclopropyl-1-[(4-fluorophenyl)sulfonyl]-5-nitro-1,2,2',3',5',6'-hexahydrospiro[indole-3,4'-thiopyran] 1',1'-dioxide](/Databaselist/images/loading.webp)
