(E)-N-((2-(3,3-dimethylbut-1-enyl)-6-(trifluoromethyl)pyridin-3-yl)methyl)-2-(3-fluoro-4-(methylsulfonamidomethyl)phenyl)propanamide

Base Information

Chemical Name:(E)-N-((2-(3,3-dimethylbut-1-enyl)-6-(trifluoromethyl)pyridin-3-yl)methyl)-2-(3-fluoro-4-(methylsulfonamidomethyl)phenyl)propanamide
CAS No.:1428744-96-0
Molecular Formula:C₂₄H₂₉F₄N₃O₃S
Molecular Weight:515.572
Hs Code.:

Synonyms:(E)-N-((2-(3,3-dimethylbut-1-enyl)-6-(trifluoromethyl)pyridin-3-yl)methyl)-2-(3-fluoro-4-(methylsulfonamidomethyl)phenyl)propanamide

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Chemical Property of (E)-N-((2-(3,3-dimethylbut-1-enyl)-6-(trifluoromethyl)pyridin-3-yl)methyl)-2-(3-fluoro-4-(methylsulfonamidomethyl)phenyl)propanamide

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Technology Process of (E)-N-((2-(3,3-dimethylbut-1-enyl)-6-(trifluoromethyl)pyridin-3-yl)methyl)-2-(3-fluoro-4-(methylsulfonamidomethyl)phenyl)propanamide

There total 6 articles about (E)-N-((2-(3,3-dimethylbut-1-enyl)-6-(trifluoromethyl)pyridin-3-yl)methyl)-2-(3-fluoro-4-(methylsulfonamidomethyl)phenyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1428745-43-0
N-((2-chloro-6-(trifluoromethyl)pyridin-3-yl)methyl)-2-(3-fluoro-4-(methylsulfonamidomethyl)phenyl)propanamide

: 1428745-61-2
(E)-((3,3-dimethylbut-1-enyl)boranediyl)dimethanol

: 1428744-96-0
(E)-N-((2-(3,3-dimethylbut-1-enyl)-6-(trifluoromethyl)pyridin-3-yl)methyl)-2-(3-fluoro-4-(methylsulfonamidomethyl)phenyl)propanamide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; water; toluene; at 100 ℃; for 1h; Microwave irradiation;

Reference yield:

: 1402586-72-4
N-[(4-bromo-2-fluorophenyl)methyl]methanesulfonamide

: 1428744-96-0
(E)-N-((2-(3,3-dimethylbut-1-enyl)-6-(trifluoromethyl)pyridin-3-yl)methyl)-2-(3-fluoro-4-(methylsulfonamidomethyl)phenyl)propanamide

Guidance literature:: Multi-step reaction with 4 steps

1: magnesium; bis(bipyridine)nickel(II) bromide; trifluoroacetic acid / N,N-dimethyl-formamide / 36 h / 65 °C / Inert atmosphere

2: lithium hydroxide; water / tetrahydrofuran / 12 h / Reflux

3: benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide; tetrahydrofuran / 36 h / 20 °C

4: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 1 h / 100 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(bipyridine)nickel(II) bromide; water; sodium carbonate; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; magnesium; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 116548-04-0
2-hydroxy-6-(trifluoromethyl)nicotinonitrile

: 1428744-96-0
(E)-N-((2-(3,3-dimethylbut-1-enyl)-6-(trifluoromethyl)pyridin-3-yl)methyl)-2-(3-fluoro-4-(methylsulfonamidomethyl)phenyl)propanamide

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate; phosphorus pentachloride / 22 h / Reflux

2: ammonia; hydrogen / isopropyl alcohol / 80 °C / 7500.75 Torr

3: benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide; tetrahydrofuran / 36 h / 20 °C

4: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 1 h / 100 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; phosphorus pentachloride; ammonia; hydrogen; sodium carbonate; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene;