ethyl 3-[2-amino-4-(2-bromo-4-fluorobenzenesulfonylamino)-3-methoxycarbonylphenyl]-furan-2-carboxylate

Base Information

Chemical Name:ethyl 3-[2-amino-4-(2-bromo-4-fluorobenzenesulfonylamino)-3-methoxycarbonylphenyl]-furan-2-carboxylate
CAS No.:1356113-84-2
Molecular Formula:C₂₁H₁₈BrFN₂O₇S
Molecular Weight:541.352
Hs Code.:

Synonyms:ethyl 3-[2-amino-4-(2-bromo-4-fluorobenzenesulfonylamino)-3-methoxycarbonylphenyl]-furan-2-carboxylate

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Chemical Property of ethyl 3-[2-amino-4-(2-bromo-4-fluorobenzenesulfonylamino)-3-methoxycarbonylphenyl]-furan-2-carboxylate

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Technology Process of ethyl 3-[2-amino-4-(2-bromo-4-fluorobenzenesulfonylamino)-3-methoxycarbonylphenyl]-furan-2-carboxylate

There total 4 articles about ethyl 3-[2-amino-4-(2-bromo-4-fluorobenzenesulfonylamino)-3-methoxycarbonylphenyl]-furan-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 351003-45-7
2-bromo-4-fluorobenzene-1-sulfonyl chloride

: 1356113-86-4
ethyl 3-(2,4-diamino-3-methoxycarbonylphenyl)-furan-2-carboxylate

: 1356113-84-2
ethyl 3-[2-amino-4-(2-bromo-4-fluorobenzenesulfonylamino)-3-methoxycarbonylphenyl]-furan-2-carboxylate

Guidance literature:: In pyridine; dichloromethane; at 20 ℃; for 2.25h;

Reference yield:

: 90050-54-7
methyl 6-amino-3-bromo-2-nitrobenzoate

: 1356113-84-2
ethyl 3-[2-amino-4-(2-bromo-4-fluorobenzenesulfonylamino)-3-methoxycarbonylphenyl]-furan-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid; iron / ethanol; water; formic acid / 2 h / 20 °C

2: caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 2 h / 20 - 70 °C / Inert atmosphere

3: dichloromethane; pyridine / 2.25 h / 20 °C

With iron; caesium carbonate; acetic acid; tri tert-butylphosphoniumtetrafluoroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; pyridine; formic acid; ethanol; dichloromethane; water;

Reference yield:

: 2-methoxycarbonyl-furan-3-boronic acid

: 1356113-84-2
ethyl 3-[2-amino-4-(2-bromo-4-fluorobenzenesulfonylamino)-3-methoxycarbonylphenyl]-furan-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 2 h / 20 - 70 °C / Inert atmosphere

2: dichloromethane; pyridine / 2.25 h / 20 °C

With caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; pyridine; dichloromethane; water;