2-acetamido-2-acetoxyacetic acid benzyl ester

Base Information

• Chemical Name: 2-acetamido-2-acetoxyacetic acid benzyl ester
• CAS No.: 446271-46-1
• Molecular Formula: C₁₃H₁₅NO₅
• Molecular Weight: 265.266
• Mol file: 446271-46-1.mol

Synonyms:2-acetamido-2-acetoxyacetic acid benzyl ester

Chemical Property of 2-acetamido-2-acetoxyacetic acid benzyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-acetamido-2-acetoxyacetic acid benzyl ester

There total 2 articles about 2-acetamido-2-acetoxyacetic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

acetic anhydride (108-24-7) + benzyl N-acetyl-α-hydroxyglycinate (446271-73-4) → 2-acetamido-2-acetoxyacetic acid benzyl ester (446271-46-1)

Guidance literature:

With pyridine; In dichloromethane; for 24h;

DOI:10.1021/jo020154s

Reference yield:

benzylglyoxylate (52709-42-9) → 2-acetamido-2-acetoxyacetic acid benzyl ester (446271-46-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 29 percent / p-toluenesulfonic acid; 3 Angstroem molecular sieves / tetrahydrofuran; various solvent(s) / 96 h / Heating

2: 76 percent / pyridine / CH₂Cl₂ / 24 h

With pyridine; 3 A molecular sieve; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo020154s

Reference yield: 96.0%

aniline (62-53-3) + 2-acetamido-2-acetoxyacetic acid benzyl ester (446271-46-1) → 2-acetamido-2-anilinoacetic acid benzyl ester (446271-48-3)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; for 16h;

DOI:10.1021/jo020154s

upstream raw materials:

acetic anhydride

benzyl N-acetyl-α-hydroxyglycinate

benzylglyoxylate

Downstream raw materials:

2-acetamido-2-anilinoacetic acid benzyl ester