tert-butyl 4-{3-[(3R)-3-{[(1S)-3-tert-butoxy-1-(5-{2-[3-(2-fluoroethoxy)phenyl]ethyl}pyridin-3-yl)-3-oxopropyl]carbamoyl}piperidin-1-yl]-3-oxopropyl}piperidine-1-carboxylate

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Chemical Name:tert-butyl 4-{3-[(3R)-3-{[(1S)-3-tert-butoxy-1-(5-{2-[3-(2-fluoroethoxy)phenyl]ethyl}pyridin-3-yl)-3-oxopropyl]carbamoyl}piperidin-1-yl]-3-oxopropyl}piperidine-1-carboxylate
CAS No.:1423135-23-2
Molecular Formula:C₄₁H₅₉FN₄O₇
Molecular Weight:738.94
Hs Code.:

tert-butyl 4-{3-[(3R)-3-{[(1S)-3-tert-butoxy-1-(5-{2-[3-(2-fluoroethoxy)phenyl]ethyl}pyridin-3-yl)-3-oxopropyl]carbamoyl}piperidin-1-yl]-3-oxopropyl}piperidine-1-carboxylate

Synonyms:tert-butyl 4-{3-[(3R)-3-{[(1S)-3-tert-butoxy-1-(5-{2-[3-(2-fluoroethoxy)phenyl]ethyl}pyridin-3-yl)-3-oxopropyl]carbamoyl}piperidin-1-yl]-3-oxopropyl}piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-{3-[(3R)-3-{[(1S)-3-tert-butoxy-1-(5-{2-[3-(2-fluoroethoxy)phenyl]ethyl}pyridin-3-yl)-3-oxopropyl]carbamoyl}piperidin-1-yl]-3-oxopropyl}piperidine-1-carboxylate

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Technology Process of tert-butyl 4-{3-[(3R)-3-{[(1S)-3-tert-butoxy-1-(5-{2-[3-(2-fluoroethoxy)phenyl]ethyl}pyridin-3-yl)-3-oxopropyl]carbamoyl}piperidin-1-yl]-3-oxopropyl}piperidine-1-carboxylate

There total 7 articles about tert-butyl 4-{3-[(3R)-3-{[(1S)-3-tert-butoxy-1-(5-{2-[3-(2-fluoroethoxy)phenyl]ethyl}pyridin-3-yl)-3-oxopropyl]carbamoyl}piperidin-1-yl]-3-oxopropyl}piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1423135-15-2
tert-butyl 4-{3-[(3R)-3-{[(1S)-3-tert-butoxy-1-(5-{[4-(2-fluoroethoxy)phenyl]ethynyl}pyridine-3-yl)-3-oxopropyl]carbamoyl}piperidin-1-yl]-3-oxopropyl}piperidine-1-carboxylate

: 1423135-23-2
tert-butyl 4-{3-[(3R)-3-{[(1S)-3-tert-butoxy-1-(5-{2-[3-(2-fluoroethoxy)phenyl]ethyl}pyridin-3-yl)-3-oxopropyl]carbamoyl}piperidin-1-yl]-3-oxopropyl}piperidine-1-carboxylate

: tert-butyl 4-{3-[(3R)-3-{[(7S)-3-tert-butoxy-1-(5-{2-[3-(2-fluoroethoxy)phenyl]ethenyl}pyridin-3-yl)-3-oxopropyl]carbamoyl}piperidin-1-yl]-3-oxopropyl}piperidine-1-carboxylate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; ethyl acetate; at 20 ℃; for 2.5h;

Reference yield:

: 35590-37-5
5-bromopyridine-3-carbonitrile

: 1423135-23-2
tert-butyl 4-{3-[(3R)-3-{[(1S)-3-tert-butoxy-1-(5-{2-[3-(2-fluoroethoxy)phenyl]ethyl}pyridin-3-yl)-3-oxopropyl]carbamoyl}piperidin-1-yl]-3-oxopropyl}piperidine-1-carboxylate

: tert-butyl 4-{3-[(3R)-3-{[(7S)-3-tert-butoxy-1-(5-{2-[3-(2-fluoroethoxy)phenyl]ethenyl}pyridin-3-yl)-3-oxopropyl]carbamoyl}piperidin-1-yl]-3-oxopropyl}piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: diisopropylamine / diethyl ether / 1 h / 0 °C

1.2: 0.5 h

1.3: 2 h / 0 °C

2.1: chloro(1,5-cyclooctadiene)rhodium(I) dimer; hydrogen; (R)-(-)-1-[((S)-2-di-tert-butylphosphino)ferrocenyl]ethyldi-(4-trifluoromethylphenyl)phosphine / 2,2,2-trifluoroethanol / 22 h / 50 °C / 8250.83 Torr

3.1: triethylamine / dichloromethane / 3 h / 0 °C

4.1: copper(l) iodide; tetrabutyl ammonium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-butylamine / tetrahydrofuran; 1,2-dimethoxyethane / 0.58 h / 80 °C

5.1: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 2.5 h / 20 °C

With copper(l) iodide; chloro(1,5-cyclooctadiene)rhodium(I) dimer; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; (R)-(-)-1-[((S)-2-di-tert-butylphosphino)ferrocenyl]ethyldi-(4-trifluoromethylphenyl)phosphine; tetrabutyl ammonium fluoride; hydrogen; N-butylamine; triethylamine; diisopropylamine; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; diethyl ether; dichloromethane; 2,2,2-trifluoroethanol; ethyl acetate; 4.1: |Sonogashira Cross-Coupling;

Reference yield:

: 1423135-32-3
tert-butyl 4-[3-((3R)-3-{[(1S)-1-(5-bromopyridin-3-yl)-3-tert-butoxy-3-oxopropyl]carbamoyl}piperidin-1-yl)-3-oxopropyl]piperidine-1-carboxylate

: 1423135-23-2
tert-butyl 4-{3-[(3R)-3-{[(1S)-3-tert-butoxy-1-(5-{2-[3-(2-fluoroethoxy)phenyl]ethyl}pyridin-3-yl)-3-oxopropyl]carbamoyl}piperidin-1-yl]-3-oxopropyl}piperidine-1-carboxylate

: tert-butyl 4-{3-[(3R)-3-{[(7S)-3-tert-butoxy-1-(5-{2-[3-(2-fluoroethoxy)phenyl]ethenyl}pyridin-3-yl)-3-oxopropyl]carbamoyl}piperidin-1-yl]-3-oxopropyl}piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; tetrabutyl ammonium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-butylamine / tetrahydrofuran; 1,2-dimethoxyethane / 0.58 h / 80 °C

2: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 2.5 h / 20 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; N-butylamine; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethyl acetate; 1: |Sonogashira Cross-Coupling;