1-(1-benzyl-1H-imidazol-4-yl)-3-[N-benzyl-N-(tert-butoxycarbonyl)amino]propene

Base Information

• Chemical Name: 1-(1-benzyl-1H-imidazol-4-yl)-3-[N-benzyl-N-(tert-butoxycarbonyl)amino]propene
• CAS No.: 941287-31-6
• Molecular Formula: C₂₅H₂₉N₃O₂
• Molecular Weight: 403.524
• Mol file: 941287-31-6.mol

Synonyms:1-(1-benzyl-1H-imidazol-4-yl)-3-[N-benzyl-N-(tert-butoxycarbonyl)amino]propene

Chemical Property of 1-(1-benzyl-1H-imidazol-4-yl)-3-[N-benzyl-N-(tert-butoxycarbonyl)amino]propene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(1-benzyl-1H-imidazol-4-yl)-3-[N-benzyl-N-(tert-butoxycarbonyl)amino]propene

There total 7 articles about 1-(1-benzyl-1H-imidazol-4-yl)-3-[N-benzyl-N-(tert-butoxycarbonyl)amino]propene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

CNH2C7H7HC2H2C3N2H2C7H7 (941287-30-5) + di-tert-butyl dicarbonate (24424-99-5) → 1-(1-benzyl-1H-imidazol-4-yl)-3-[N-benzyl-N-(tert-butoxycarbonyl)amino]propene (941287-31-6)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1021/jo0626008

Reference yield:

(2E)-3-(1-benzyl-1H-imidazol-4-yl)propenal (941287-29-2) → 1-(1-benzyl-1H-imidazol-4-yl)-3-[N-benzyl-N-(tert-butoxycarbonyl)amino]propene (941287-31-6)

Guidance literature:

Multi-step reaction with 3 steps

1: molecular sieves 4 Angstroem / methanol / 3 h

2: NaBH₄; MeOH / 5 h

3: 718 mg / Et₃N; DMAP / CH₂Cl₂ / 20 °C

With methanol; dmap; sodium tetrahydroborate; 4 A molecular sieve; triethylamine; In methanol; dichloromethane;

DOI:10.1021/jo0626008

Reference yield:

CNC7H7HC2H2C3N2H2C7H7 → 1-(1-benzyl-1H-imidazol-4-yl)-3-[N-benzyl-N-(tert-butoxycarbonyl)amino]propene (941287-31-6)

Guidance literature:

Multi-step reaction with 2 steps

1: NaBH₄; MeOH / 5 h

2: 718 mg / Et₃N; DMAP / CH₂Cl₂ / 20 °C

With methanol; dmap; sodium tetrahydroborate; triethylamine; In dichloromethane;

DOI:10.1021/jo0626008

upstream raw materials:

CNH₂C₇H₇HC₂H₂C₃N₂H₂C₇H₇

di-tert-butyl dicarbonate

(2E)-3-(1-benzyl-1H-imidazol-4-yl)propenal

benzyl chloride