(R)-5-((2-(4-(1-(2-hydroxypropyl)piperidin-4-yl)benzamide)pyridin-4-yl)oxy)-6-isopropoxy-N-methyl-1H-indole-1-carboxamide

Base Information

Chemical Name:(R)-5-((2-(4-(1-(2-hydroxypropyl)piperidin-4-yl)benzamide)pyridin-4-yl)oxy)-6-isopropoxy-N-methyl-1H-indole-1-carboxamide
CAS No.:1622204-17-4
Molecular Formula:C₃₃H₃₉N₅O₅
Molecular Weight:585.703
Hs Code.:

Synonyms:(R)-5-((2-(4-(1-(2-hydroxypropyl)piperidin-4-yl)benzamide)pyridin-4-yl)oxy)-6-isopropoxy-N-methyl-1H-indole-1-carboxamide

Suppliers and Price of (R)-5-((2-(4-(1-(2-hydroxypropyl)piperidin-4-yl)benzamide)pyridin-4-yl)oxy)-6-isopropoxy-N-methyl-1H-indole-1-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-5-((2-(4-(1-(2-hydroxypropyl)piperidin-4-yl)benzamide)pyridin-4-yl)oxy)-6-isopropoxy-N-methyl-1H-indole-1-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-5-((2-(4-(1-(2-hydroxypropyl)piperidin-4-yl)benzamide)pyridin-4-yl)oxy)-6-isopropoxy-N-methyl-1H-indole-1-carboxamide

There total 14 articles about (R)-5-((2-(4-(1-(2-hydroxypropyl)piperidin-4-yl)benzamide)pyridin-4-yl)oxy)-6-isopropoxy-N-methyl-1H-indole-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1622204-16-3
6-isopropoxy-N-methyl-5-((2-(4-(piperidin-4-yl)benzamide)pyridin-4-yl)oxy)-1H-indole-1-carboxamide

: 15448-47-2
(R)-propylene oxide

: 1622204-17-4
(R)-5-((2-(4-(1-(2-hydroxypropyl)piperidin-4-yl)benzamide)pyridin-4-yl)oxy)-6-isopropoxy-N-methyl-1H-indole-1-carboxamide

Guidance literature:: In ethanol; at 80 ℃; for 3.66667h; Sealed tube;

Reference yield:

: 1622205-48-4
5-((2-aminopyridin-4-yl)oxy)-6-isopropoxy-N-methyl-1H-indole-1-carboxamide

: 1622204-17-4
(R)-5-((2-(4-(1-(2-hydroxypropyl)piperidin-4-yl)benzamide)pyridin-4-yl)oxy)-6-isopropoxy-N-methyl-1H-indole-1-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,2,3-Benzotriazole; thionyl chloride / dichloromethane / 0.92 h / 20 °C / Inert atmosphere

1.2: 2.33 h / 0 - 20 °C

2.1: trifluoroacetic acid / dichloromethane / 1.5 h / 0 - 20 °C

3.1: ethanol / 3.67 h / 80 °C / Sealed tube

With 1,2,3-Benzotriazole; thionyl chloride; trifluoroacetic acid; In ethanol; dichloromethane;

Reference yield:

: 94283-73-5
3-hydroxy-4-isopropoxy benzaldehyde

: 1622204-17-4
(R)-5-((2-(4-(1-(2-hydroxypropyl)piperidin-4-yl)benzamide)pyridin-4-yl)oxy)-6-isopropoxy-N-methyl-1H-indole-1-carboxamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: potassium carbonate / ethanol / 2 h / 90 °C / Inert atmosphere

2.1: acetic acid; ammonium acetate / 2 h / 130 °C / Inert atmosphere

3.1: acetic acid; nitric acid / 7.5 h / 20 °C

4.1: palladium 10% on activated carbon; hydrogen / methanol; water / 14.5 h

5.1: potassium tert-butylate / dimethyl sulfoxide / 3 h / 160 °C / Inert atmosphere

6.1: methanol; sodium methylate / 3 h / 70 °C / Inert atmosphere

7.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.83 h / 0 - 20 °C

7.2: 3 h / 0 - 20 °C

8.1: 1,2,3-Benzotriazole; thionyl chloride / dichloromethane / 0.92 h / 20 °C / Inert atmosphere

8.2: 2.33 h / 0 - 20 °C

9.1: trifluoroacetic acid / dichloromethane / 1.5 h / 0 - 20 °C

10.1: ethanol / 3.67 h / 80 °C / Sealed tube

With methanol; 1,2,3-Benzotriazole; thionyl chloride; palladium 10% on activated carbon; potassium tert-butylate; ammonium acetate; hydrogen; nitric acid; sodium methylate; sodium hydride; potassium carbonate; acetic acid; trifluoroacetic acid; In methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;