1-(3-O-Benzyl-4-C-(4,4'-dimethoxytrityloxymethyl)-β-D-xylofuranosyl)thymine

Base Information

• Chemical Name: 1-(3-O-Benzyl-4-C-(4,4'-dimethoxytrityloxymethyl)-β-D-xylofuranosyl)thymine
• CAS No.: 296253-24-2
• Molecular Formula: C₃₉H₄₀N₂O₉
• Molecular Weight: 680.755

Synonyms:1-(3-O-Benzyl-4-C-(4,4'-dimethoxytrityloxymethyl)-β-D-xylofuranosyl)thymine

Chemical Property of 1-(3-O-Benzyl-4-C-(4,4'-dimethoxytrityloxymethyl)-β-D-xylofuranosyl)thymine

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Technology Process of 1-(3-O-Benzyl-4-C-(4,4'-dimethoxytrityloxymethyl)-β-D-xylofuranosyl)thymine

There total 2 articles about 1-(3-O-Benzyl-4-C-(4,4'-dimethoxytrityloxymethyl)-β-D-xylofuranosyl)thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + 1-(3-O-Benzyl-4-C-hydroxymethyl-α-L-threo-pentofuranosyl)thymine (230631-18-2) → 1-(3-O-Benzyl-4-C-(4,4'-dimethoxytrityloxymethyl)-β-D-xylofuranosyl)thymine (296253-24-2)

Guidance literature:

With pyridine; silver nitrate; In tetrahydrofuran; at 20 ℃; for 18h; without light;

Reference yield: 31.0%

nucleoside 1-(3-O-Benzyl-4-C-hydroxymethyl-β-D-xylofuranosyl)thymine + 1-(3-O-Benzy-4-hydroxymethyl-β-D-xylofuranosyl)thymine + 4,4'-dimethoxytrityl chloride (40615-36-9) → 1-(3-O-Benzyl-4-C-(4,4'-dimethoxytrityloxymethyl)-β-D-xylofuranosyl)thymine (296253-24-2)

Guidance literature:

With pyridine; sodium bicarbonate; silver nitrate; In tetrahydrofuran; methanol; dichloromethane;

Reference yield: 62.0%

1-(3-O-Benzyl-4-C-(4,4'-dimethoxytrityloxymethyl)-β-D-xylofuranosyl)thymine (296253-24-2) + p-toluenesulfonyl chloride (98-59-9) → 1-(3-O-Benzyl-4-C-(4,4'-dimethoxytrityloxymethyl)-2,5-di-O-(p-toluenesulphonyl)-β-D-xylofuranosyl)thymine (296253-26-4)

Guidance literature:

With sodium bicarbonate; sodium chloride; dmap; In pyridine; methanol; dichloromethane;

upstream raw materials:

4,4'-dimethoxytrityl chloride

1-(3-O-Benzyl-4-C-hydroxymethyl-α-L-threo-pentofuranosyl)thymine

Downstream raw materials:

1-(3-O-Benzyl-4-C-(4,4'-dimethoxytrityloxymethyl)-2,5-di-O-(p-toluenesulphonyl)-β-D-xylofuranosyl)thymine

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