ethyl (2E)-3-(1-{(2S)-2-[(S)-(3,5-dimethoxy-4-methylphenyl)(hydroxy)methyl]-5-phenylpentyl}-1H-pyrazol-4-yl)acrylate

Base Information

• Chemical Name: ethyl (2E)-3-(1-{(2S)-2-[(S)-(3,5-dimethoxy-4-methylphenyl)(hydroxy)methyl]-5-phenylpentyl}-1H-pyrazol-4-yl)acrylate
• CAS No.: 856688-72-7
• Molecular Formula: C₃₅H₅₀N₂O₅Si
• Molecular Weight: 606.878

Synonyms:ethyl (2E)-3-(1-{(2S)-2-[(S)-(3,5-dimethoxy-4-methylphenyl)(hydroxy)methyl]-5-phenylpentyl}-1H-pyrazol-4-yl)acrylate

Chemical Property of ethyl (2E)-3-(1-{(2S)-2-[(S)-(3,5-dimethoxy-4-methylphenyl)(hydroxy)methyl]-5-phenylpentyl}-1H-pyrazol-4-yl)acrylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl (2E)-3-(1-{(2S)-2-[(S)-(3,5-dimethoxy-4-methylphenyl)(hydroxy)methyl]-5-phenylpentyl}-1H-pyrazol-4-yl)acrylate

There total 10 articles about ethyl (2E)-3-(1-{(2S)-2-[(S)-(3,5-dimethoxy-4-methylphenyl)(hydroxy)methyl]-5-phenylpentyl}-1H-pyrazol-4-yl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

diethoxyphosphoryl-acetic acid ethyl ester (867-13-0) + 1-{(2S)-2-[(S)-(3,5-dimethoxy-4-methylphenyl)(hydroxy)methyl]-5-phenylpentyl}-1H-pyrazole-4-carbaldehyde (856688-70-5) → ethyl (2E)-3-(1-{(2S)-2-[(S)-(3,5-dimethoxy-4-methylphenyl)(hydroxy)methyl]-5-phenylpentyl}-1H-pyrazol-4-yl)acrylate (856688-72-7)

Guidance literature:

diethoxyphosphoryl-acetic acid ethyl ester; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.166667h;

1-{(2S)-2-[(S)-(3,5-dimethoxy-4-methylphenyl)(hydroxy)methyl]-5-phenylpentyl}-1H-pyrazole-4-carbaldehyde; In tetrahydrofuran; mineral oil; at 20 ℃; for 0.5h;

DOI:10.1021/acsmedchemlett.7b00383

Reference yield:

3,5-dimethoxy-4-methylbenzaldehyde (1011-27-4) → ethyl (2E)-3-(1-{(2S)-2-[(S)-(3,5-dimethoxy-4-methylphenyl)(hydroxy)methyl]-5-phenylpentyl}-1H-pyrazol-4-yl)acrylate (856688-72-7)

Guidance literature:

Multi-step reaction with 9 steps

1.1: triethylamine; chloro-trimethyl-silane; magnesium chloride / ethyl acetate / 20 °C

1.2: 0.08 h

2.1: 2,6-dimethylpyridine / dichloromethane / 2 h / 0 °C

3.1: lithium borohydride / tetrahydrofuran; water / 3 h / 0 - 20 °C / Inert atmosphere

4.1: triethylamine / tetrahydrofuran / 0.25 h / 0 - 20 °C

5.1: sodium iodide / acetone / 3 h / 90 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C

7.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.25 h / 20 °C

8.1: triethylamine; sulfur trioxide pyridine complex / dimethyl sulfoxide / 1 h / 20 °C

9.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 0 °C

9.2: 0.5 h / 20 °C

With 2,6-dimethylpyridine; lithium aluminium tetrahydride; lithium borohydride; chloro-trimethyl-silane; sulfur trioxide pyridine complex; sodium hydride; potassium carbonate; triethylamine; sodium iodide; magnesium chloride; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; acetone; mineral oil;

DOI:10.1021/acsmedchemlett.7b00383

Reference yield:

(4S)-4-benzyl-3-(5-phenylpentanoyl)-1,3-oxazolidin-2-one (161725-13-9) → ethyl (2E)-3-(1-{(2S)-2-[(S)-(3,5-dimethoxy-4-methylphenyl)(hydroxy)methyl]-5-phenylpentyl}-1H-pyrazol-4-yl)acrylate (856688-72-7)

Guidance literature:

Multi-step reaction with 9 steps

1.1: triethylamine; chloro-trimethyl-silane; magnesium chloride / ethyl acetate / 20 °C

1.2: 0.08 h

2.1: 2,6-dimethylpyridine / dichloromethane / 2 h / 0 °C

3.1: lithium borohydride / tetrahydrofuran; water / 3 h / 0 - 20 °C / Inert atmosphere

4.1: triethylamine / tetrahydrofuran / 0.25 h / 0 - 20 °C

5.1: sodium iodide / acetone / 3 h / 90 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C

7.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.25 h / 20 °C

8.1: triethylamine; sulfur trioxide pyridine complex / dimethyl sulfoxide / 1 h / 20 °C

9.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 0 °C

9.2: 0.5 h / 20 °C

With 2,6-dimethylpyridine; lithium aluminium tetrahydride; lithium borohydride; chloro-trimethyl-silane; sulfur trioxide pyridine complex; sodium hydride; potassium carbonate; triethylamine; sodium iodide; magnesium chloride; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; acetone; mineral oil;

DOI:10.1021/acsmedchemlett.7b00383

upstream raw materials:

diethoxyphosphoryl-acetic acid ethyl ester

1-{(2S)-2-[(S)-(3,5-dimethoxy-4-methylphenyl)(hydroxy)methyl]-5-phenylpentyl}-1H-pyrazole-4-carbaldehyde

3,5-dimethoxy-4-methylbenzaldehyde

(4S)-4-benzyl-3-(5-phenylpentanoyl)-1,3-oxazolidin-2-one

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 856688-72-7 ethyl (2E)-3-(1-{(2S)-2-[(S)-(3,5-dimethoxy-4-methylphenyl)(hydroxy)methyl]-5-phenylpentyl}-1H-pyrazol-4-yl)acrylate

Send

Send

Metric Ton KG G Pound L ML

Send

Send