11-(3-bromo-2,6-dimethylphenyl)-12-hydroxy-1,4-dioxa-9-azadispiro[4.2.4.2]tetradec-11-en-10-one

Base Information

Chemical Name:11-(3-bromo-2,6-dimethylphenyl)-12-hydroxy-1,4-dioxa-9-azadispiro[4.2.4.2]tetradec-11-en-10-one
CAS No.:1329580-38-2
Molecular Formula:C₁₉H₂₂BrNO₄
Molecular Weight:408.292
Hs Code.:

Synonyms:11-(3-bromo-2,6-dimethylphenyl)-12-hydroxy-1,4-dioxa-9-azadispiro[4.2.4.2]tetradec-11-en-10-one

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Chemical Property of 11-(3-bromo-2,6-dimethylphenyl)-12-hydroxy-1,4-dioxa-9-azadispiro[4.2.4.2]tetradec-11-en-10-one

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Technology Process of 11-(3-bromo-2,6-dimethylphenyl)-12-hydroxy-1,4-dioxa-9-azadispiro[4.2.4.2]tetradec-11-en-10-one

There total 3 articles about 11-(3-bromo-2,6-dimethylphenyl)-12-hydroxy-1,4-dioxa-9-azadispiro[4.2.4.2]tetradec-11-en-10-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1329580-36-0
methyl 8-{[(3-bromo-2,6-dimethylphenyl)acetyl]amino}-1,4-dioxaspiro[4.5]decane-8-carboxylate

: 1329580-38-2
11-(3-bromo-2,6-dimethylphenyl)-12-hydroxy-1,4-dioxa-9-azadispiro[4.2.4.2]tetradec-11-en-10-one

Guidance literature:: With potassium tert-butylate; In N,N-dimethyl-formamide; at 80 ℃; for 0.5h;

Reference yield:

: 197711-04-9
2-(3-bromo-2,6-dimethylphenyl)acetic acid

: 1329580-38-2
11-(3-bromo-2,6-dimethylphenyl)-12-hydroxy-1,4-dioxa-9-azadispiro[4.2.4.2]tetradec-11-en-10-one

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / 4 h / 80 °C

2: triethylamine; dmap / dichloromethane / 20 °C

3: potassium tert-butylate / N,N-dimethyl-formamide / 0.5 h / 80 °C

With dmap; thionyl chloride; potassium tert-butylate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1329581-37-4
(3-bromo-2,6-dimethylphenyl)acetyl chloride

: 1329580-38-2
11-(3-bromo-2,6-dimethylphenyl)-12-hydroxy-1,4-dioxa-9-azadispiro[4.2.4.2]tetradec-11-en-10-one

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; dmap / dichloromethane / 20 °C

2: potassium tert-butylate / N,N-dimethyl-formamide / 0.5 h / 80 °C

With dmap; potassium tert-butylate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;