3,3-ethylenedioxy-5α,17β-dihydroxy-11β-[4-(N,N-dimethylamino)phenyl]-19-nor-17α-pregn-9-ene-21-carbonitrile

Base Information

Chemical Name:3,3-ethylenedioxy-5α,17β-dihydroxy-11β-[4-(N,N-dimethylamino)phenyl]-19-nor-17α-pregn-9-ene-21-carbonitrile
CAS No.:216372-24-6
Molecular Formula:C₃₁H₄₂N₂O₄
Molecular Weight:506.685
Hs Code.:

Synonyms:3,3-ethylenedioxy-5α,17β-dihydroxy-11β-[4-(N,N-dimethylamino)phenyl]-19-nor-17α-pregn-9-ene-21-carbonitrile

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Chemical Property of 3,3-ethylenedioxy-5α,17β-dihydroxy-11β-[4-(N,N-dimethylamino)phenyl]-19-nor-17α-pregn-9-ene-21-carbonitrile

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Technology Process of 3,3-ethylenedioxy-5α,17β-dihydroxy-11β-[4-(N,N-dimethylamino)phenyl]-19-nor-17α-pregn-9-ene-21-carbonitrile

There total 4 articles about 3,3-ethylenedioxy-5α,17β-dihydroxy-11β-[4-(N,N-dimethylamino)phenyl]-19-nor-17α-pregn-9-ene-21-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5571-36-8
ethylene deltenone

: 216372-24-6
3,3-ethylenedioxy-5α,17β-dihydroxy-11β-[4-(N,N-dimethylamino)phenyl]-19-nor-17α-pregn-9-ene-21-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 59.76 percent / 30percent H₂O₂, hexafluoroacetone trihydrate, Na₂HPO₄ / CH₂Cl₂ / 18 h / 0 - 4 °C

2: 1.) CuCl / 1.) THF, RT, 30 min, 2.) THF, from -30 deg C to -20 deg C, 3 h

3: 1.) NaH, DMSO / 1.) THF, from -5 deg C to 0 deg C, 35 min, 2.) THF, 0 deg C, 3 h

4: 1.) lithium diisopropylamide mono(tetrahydrofuran) / 1.) THF, cyclohexane, -30 deg C, 30 min, 2.) THF, cyclohexane, RT, 6 h

With disodium hydrogenphosphate; dihydrogen peroxide; sodium hydride; dimethyl sulfoxide; lithium diisopropylamide mono(tetrahydrofuran); Hexafluoroacetone; copper(l) chloride; In dichloromethane;
DOI:10.1016/S0039-128X(98)00060-9

Reference yield:

: 39931-88-9,116003-08-8,39931-87-8
(5'R,10'R,13'S)-13'-methyl-1',2',6',7',8',12',13',14',15',16'-decahydro-17'H-spiro[1,3-dioxolane-2,3'-[5,10]epoxycyclopenta[a]phenanthren]-17'-one

: 216372-24-6
3,3-ethylenedioxy-5α,17β-dihydroxy-11β-[4-(N,N-dimethylamino)phenyl]-19-nor-17α-pregn-9-ene-21-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) CuCl / 1.) THF, RT, 30 min, 2.) THF, from -30 deg C to -20 deg C, 3 h

2: 1.) NaH, DMSO / 1.) THF, from -5 deg C to 0 deg C, 35 min, 2.) THF, 0 deg C, 3 h

3: 1.) lithium diisopropylamide mono(tetrahydrofuran) / 1.) THF, cyclohexane, -30 deg C, 30 min, 2.) THF, cyclohexane, RT, 6 h

With sodium hydride; dimethyl sulfoxide; lithium diisopropylamide mono(tetrahydrofuran); copper(l) chloride;
DOI:10.1016/S0039-128X(98)00060-9

Reference yield:

: 91934-77-9
(5R,8S,11R,13S,14S)-11-(4-(dimethylamino)phenyl)-5-hydroxy-13-methyl-1,4,5,6,7,8,11,12,13,14,15,16-dodecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxolan]-17(2H)-one

: 216372-24-6
3,3-ethylenedioxy-5α,17β-dihydroxy-11β-[4-(N,N-dimethylamino)phenyl]-19-nor-17α-pregn-9-ene-21-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH, DMSO / 1.) THF, from -5 deg C to 0 deg C, 35 min, 2.) THF, 0 deg C, 3 h

2: 1.) lithium diisopropylamide mono(tetrahydrofuran) / 1.) THF, cyclohexane, -30 deg C, 30 min, 2.) THF, cyclohexane, RT, 6 h

With sodium hydride; dimethyl sulfoxide; lithium diisopropylamide mono(tetrahydrofuran);
DOI:10.1016/S0039-128X(98)00060-9