3-[(Z)-1-fluoro-2-{4-[(trifluoromethyl)sulphanyl]phenyl}vinyl]-5-methyl-1-(4-methylbenzyl)-1H-pyrazole

Base Information

Chemical Name:3-[(Z)-1-fluoro-2-{4-[(trifluoromethyl)sulphanyl]phenyl}vinyl]-5-methyl-1-(4-methylbenzyl)-1H-pyrazole
CAS No.:1418295-64-3
Molecular Formula:C₂₁H₁₈F₄N₂S
Molecular Weight:406.447
Hs Code.:

Synonyms:3-[(Z)-1-fluoro-2-{4-[(trifluoromethyl)sulphanyl]phenyl}vinyl]-5-methyl-1-(4-methylbenzyl)-1H-pyrazole

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Chemical Property of 3-[(Z)-1-fluoro-2-{4-[(trifluoromethyl)sulphanyl]phenyl}vinyl]-5-methyl-1-(4-methylbenzyl)-1H-pyrazole

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Technology Process of 3-[(Z)-1-fluoro-2-{4-[(trifluoromethyl)sulphanyl]phenyl}vinyl]-5-methyl-1-(4-methylbenzyl)-1H-pyrazole

There total 8 articles about 3-[(Z)-1-fluoro-2-{4-[(trifluoromethyl)sulphanyl]phenyl}vinyl]-5-methyl-1-(4-methylbenzyl)-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 4021-50-5
4-(trifluoromethylthio)benzaldehyde

: 1418296-83-9
2-({fluoro[5-methyl-1-(4-methylbenzyl)-1H-pyrazol-3-yl]methyl}sulphonyl)-1,3-benzothiazole

: 1418295-64-3
3-[(Z)-1-fluoro-2-{4-[(trifluoromethyl)sulphanyl]phenyl}vinyl]-5-methyl-1-(4-methylbenzyl)-1H-pyrazole

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; ethylbenzene; at 0 ℃; for 3h; Inert atmosphere;

Reference yield:

: 20577-61-1
methyl 2,4-dioxopentanoate

: 1418295-64-3
3-[(Z)-1-fluoro-2-{4-[(trifluoromethyl)sulphanyl]phenyl}vinyl]-5-methyl-1-(4-methylbenzyl)-1H-pyrazole

Guidance literature:: Multi-step reaction with 8 steps

1: acetic acid / 4 h / 90 °C

2: water; sodium hydroxide / ethanol / 70 °C

3: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 3 h / 0 - 20 °C

4: triphenylphosphine; carbon tetrabromide / dichloromethane / 32 h / 20 °C

5: N,N-dimethyl-formamide / 1 h / 20 °C

6: 3-chloro-benzenecarboperoxoic acid / dichloromethane; water / 24 h / 20 °C

7: N-fluorobis(benzenesulfon)imide; lithium diisopropyl amide / tetrahydrofuran; toluene; hexane; ethylbenzene / -78 - 20 °C

8: lithium hexamethyldisilazane / tetrahydrofuran; ethylbenzene / 3 h / 0 °C / Inert atmosphere

With lithium aluminium tetrahydride; carbon tetrabromide; water; acetic acid; N-fluorobis(benzenesulfon)imide; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; sodium hydroxide; lithium hexamethyldisilazane; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; ethanol; hexane; dichloromethane; ethylbenzene; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 51421-17-1
4-methylbenzylhydrazine

: 1418295-64-3
3-[(Z)-1-fluoro-2-{4-[(trifluoromethyl)sulphanyl]phenyl}vinyl]-5-methyl-1-(4-methylbenzyl)-1H-pyrazole

Guidance literature:: Multi-step reaction with 8 steps

1: acetic acid / 4 h / 90 °C

2: water; sodium hydroxide / ethanol / 70 °C

3: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 3 h / 0 - 20 °C

4: triphenylphosphine; carbon tetrabromide / dichloromethane / 32 h / 20 °C

5: N,N-dimethyl-formamide / 1 h / 20 °C

6: 3-chloro-benzenecarboperoxoic acid / dichloromethane; water / 24 h / 20 °C

7: N-fluorobis(benzenesulfon)imide; lithium diisopropyl amide / tetrahydrofuran; toluene; hexane; ethylbenzene / -78 - 20 °C

8: lithium hexamethyldisilazane / tetrahydrofuran; ethylbenzene / 3 h / 0 °C / Inert atmosphere

With lithium aluminium tetrahydride; carbon tetrabromide; water; acetic acid; N-fluorobis(benzenesulfon)imide; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; sodium hydroxide; lithium hexamethyldisilazane; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; ethanol; hexane; dichloromethane; ethylbenzene; water; N,N-dimethyl-formamide; toluene;