9-{2-[(4,7-diisobutoxy-9-phenylcarbamoyl-[1,10]phenanthroline-2-carbonyl)-amino]-phenylcarbamoyl}-4,7-diisobutoxy-[1,10]phenanthroline-2-carboxylic acid methyl ester

Base Information

• Chemical Name: 9-{2-[(4,7-diisobutoxy-9-phenylcarbamoyl-[1,10]phenanthroline-2-carbonyl)-amino]-phenylcarbamoyl}-4,7-diisobutoxy-[1,10]phenanthroline-2-carboxylic acid methyl ester
• CAS No.: 877869-13-1
• Molecular Formula: C₅₇H₅₉N₇O₉
• Molecular Weight: 986.137
• Mol file: 877869-13-1.mol

Synonyms:9-{2-[(4,7-diisobutoxy-9-phenylcarbamoyl-[1,10]phenanthroline-2-carbonyl)-amino]-phenylcarbamoyl}-4,7-diisobutoxy-[1,10]phenanthroline-2-carboxylic acid methyl ester

Chemical Property of 9-{2-[(4,7-diisobutoxy-9-phenylcarbamoyl-[1,10]phenanthroline-2-carbonyl)-amino]-phenylcarbamoyl}-4,7-diisobutoxy-[1,10]phenanthroline-2-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9-{2-[(4,7-diisobutoxy-9-phenylcarbamoyl-[1,10]phenanthroline-2-carbonyl)-amino]-phenylcarbamoyl}-4,7-diisobutoxy-[1,10]phenanthroline-2-carboxylic acid methyl ester

There total 14 articles about 9-{2-[(4,7-diisobutoxy-9-phenylcarbamoyl-[1,10]phenanthroline-2-carbonyl)-amino]-phenylcarbamoyl}-4,7-diisobutoxy-[1,10]phenanthroline-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

4,7-diisobutoxy-[1,10]phenanthroline-2,9-dicarboxylic acid monomethyl ester (877869-12-0) + 4,7-diisobutoxy-[1,10]phenanthroline-2,9-dicarboxylic acid 2-[(2-amino-phenyl)-amide] 9-phenylamide (877869-08-4) → 9-{2-[(4,7-diisobutoxy-9-phenylcarbamoyl-[1,10]phenanthroline-2-carbonyl)-amino]-phenylcarbamoyl}-4,7-diisobutoxy-[1,10]phenanthroline-2-carboxylic acid methyl ester (877869-13-1)

Guidance literature:

With dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1021/jo052222r

Reference yield:

4-isobutoxy-8-nitroquinoline-2-carboxylic acid phenylamide (877869-02-8) → 9-{2-[(4,7-diisobutoxy-9-phenylcarbamoyl-[1,10]phenanthroline-2-carbonyl)-amino]-phenylcarbamoyl}-4,7-diisobutoxy-[1,10]phenanthroline-2-carboxylic acid methyl ester (877869-13-1)

Guidance literature:

Multi-step reaction with 7 steps

1: 100 percent / hydrogen / Pd/C / CH₂Cl₂ / 10 h / 20 °C

2: 71 percent / methanol / 8 h / 20 °C

3: 54 percent / diphenyl ether / 0.5 h / Heating

4: 71.8 percent / triphenylphosphine; diisopropyl azodicarboxylate / tetrahydrofuran / 8.5 h / 0 - 20 °C

5: 100 percent / KOH / methanol; tetrahydrofuran / 5 h / 20 °C

6: 70.5 percent / N,N'-dicyclohexylcarbodiimide / CH₂Cl₂ / 24 h / 20 °C

7: 75 percent / N,N'-dicyclohexylcarbodiimide / CH₂Cl₂ / 24 h / 20 °C

With potassium hydroxide; di-isopropyl azodicarboxylate; hydrogen; dicyclohexyl-carbodiimide; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; methanol; diphenylether; dichloromethane;

DOI:10.1021/jo052222r

Reference yield:

methyl 4-isobutoxyl-8-nitroquinoline-2-carboxylate (517883-19-1) → 9-{2-[(4,7-diisobutoxy-9-phenylcarbamoyl-[1,10]phenanthroline-2-carbonyl)-amino]-phenylcarbamoyl}-4,7-diisobutoxy-[1,10]phenanthroline-2-carboxylic acid methyl ester (877869-13-1)

Guidance literature:

Multi-step reaction with 10 steps

1: 100 percent / KOH / tetrahydrofuran; methanol / 5 h / 20 °C

2: SOCl₂ / 2 h / Heating

3: 0.34 g / CH₂Cl₂ / 4 h / 20 °C

4: 100 percent / hydrogen / Pd/C / CH₂Cl₂ / 10 h / 20 °C

5: 71 percent / methanol / 8 h / 20 °C

6: 54 percent / diphenyl ether / 0.5 h / Heating

7: 71.8 percent / triphenylphosphine; diisopropyl azodicarboxylate / tetrahydrofuran / 8.5 h / 0 - 20 °C

8: 100 percent / KOH / methanol; tetrahydrofuran / 5 h / 20 °C

9: 70.5 percent / N,N'-dicyclohexylcarbodiimide / CH₂Cl₂ / 24 h / 20 °C

10: 75 percent / N,N'-dicyclohexylcarbodiimide / CH₂Cl₂ / 24 h / 20 °C

With potassium hydroxide; thionyl chloride; di-isopropyl azodicarboxylate; hydrogen; dicyclohexyl-carbodiimide; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; methanol; diphenylether; dichloromethane;

DOI:10.1021/jo052222r

upstream raw materials:

4,7-diisobutoxy-[1,10]phenanthroline-2,9-dicarboxylic acid monomethyl ester

4,7-diisobutoxy-[1,10]phenanthroline-2,9-dicarboxylic acid 2-[(2-amino-phenyl)-amide] 9-phenylamide

8-amino-4-isobutoxyquinoline-2-carboxylic acid phenylamide

4-isobutoxy-8-nitroquinoline-2-carboxylic acid phenylamide

Downstream raw materials:

C₆₂H₆₃N₉O₈

9-{2-[(4,7-diisobutoxy-9-phenylcarbamoyl-[1,10]phenanthroline-2-carbonyl)-amino]-phenylcarbamoyl}-4,7-diisobutoxy-[1,10]phenanthroline-2-carboxylic acid